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应用受试者工作特性曲线评价D-二聚体与糖类抗原153联合检测对乳腺癌的诊断价值 被引量:2

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摘要 目的探讨D-二聚体和糖类抗原153(CA153)联合检测对乳腺癌的诊断价值。方法分别采用免疫比浊法和电化学发光法检测血浆D二聚体和血清CA153水平,应用受试者工作特性曲线(ROC曲线)对68例乳腺癌患者(乳腺癌组)、50例乳腺良性疾病患者(良性疾病组)以及50例健康体检者(正常对照组)的D-二聚体、CA153以及两者联合检测结果进行分析评价。结果 1乳腺癌组血清D-二聚体与CA153水平显著高于良性疾病组以及正常对照组,差异有统计学意义(P<0.05),二者在良性疾病组与正常对照组之间差异无统计学意义(P>0.05)。2D-二聚体和CA153在乳腺癌组的灵敏度分别为38.24%、63.24%,两者联合检测的灵敏度明显提高为75.00%。3乳腺癌组的D-二聚体、CA153以及两者联合检测在ROC曲线下的面积分别为0.711、0.814、0.849。结论 D-二聚体和CA153联合检测可提高乳腺癌诊断的灵敏度和有效性。
出处 《中国妇幼保健》 CAS 2015年第32期5697-5698,共2页 Maternal and Child Health Care of China
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