儿童急性泛发性脓疱型银屑病外周血参数分析

Analysis of peripheral blood parameter in children patients with acute generalized pustular psoriasis

目的:明确儿童急性泛发型脓疱性银屑病(AGPP)血小板参数、C反应蛋白(CRP)及嗜酸粒细胞水平变化。方法:检测41例儿童AGPP患者、37例健康儿童对照及31例儿童寻常型银屑病患者(PV)血小板参数、CRP及嗜酸粒细胞水平。结果:AGPP进展期PLT计数、血小板压积(PCT),CRP均显著高于儿童PV患者及儿童正常对照组(P<0.05)。进展期AGPP患者嗜酸粒细胞百分比和平均血小板体积(MPV)显著低于其他两组(P<0.05)。嗜酸粒细胞计数与对照组无明显差异(P>0.05)。消退期AGPP患者PLT计数、PCT及CRP显著低于进展期AGPP患者(P<0.05)。结论:血小板参数及CRP水平可作为AGPP病程进展及治疗评价的参考指标。

Objective： To determine the changes of the levels of peripheral blood platelet parameters,Creactive protein（ CRP） and eosnophils（ EOS） in children with acute generalized pustular psoriasis（ AGPP）.Methods： The levels of peripheral blood platelet parameters,CRP and EOS in 41 children with AGPP,37 healthy children and 31 children with psoriasis vulgaris were detected. Results： The levels of PLT count,platelet hematocrit（ PCT） and CRP in the active stage of AGPP group were higher than those in the other two groups（ P〈0. 05）. The mean platelet volume（ MPV） and EOS percentage were lower than those in the other two groups（ P〈0. 05）. There was no significant difference of EOS count among the three groups（ P〉0.05）. The levels of PLT count,PCT and CRP in the recovery stage of AGPP were lower than those in active stage. Conclusion： Platelet parameters and CRP level could be as assistant indicators in monitoring the progression of children with AGPP.