饮食疗法、口服益生菌联合艾迪莎气药灌肠对溃疡性结肠炎的临床疗效

Clinical effects of diet therapy plus oral probiotics plus Etiasa gas enema in ulcerative colitis

目的:研究饮食疗法联合基础治疗(口服益生菌、艾迪莎联合气药灌肠)对溃疡性结肠炎的临床疗效.方法:选取南京市中医院2014-01/2015-03收治的90例中度及中度以下的溃疡性结肠炎患者,电脑随机分为实验组、对照组和空白组.实验组和对照组口服相同药物治疗的同时实验组严格控制饮食,两组常规口服益生菌、艾迪莎联合气药灌肠.实验组和空白组同时严格遵守医生交代的饮食习惯.观察三组治疗前后的炎性指标变化[白细胞、红细胞沉降率(erythrocyte sedimentation rate,ESR)、C-反应蛋白(C-reaction protein,CRP)].结果:实验组总缓解率大于对照组和空白组(实验组90%,对照组83.3%,空白组80.0%).相关炎性治疗中,ESR和CRP治疗前后有统计学意义,实验组优于对照组和空白组(3组ESR组间治疗前F=1.796,P=0.172>0.05,认为各组回归直线是平行的.进行协方差分析,治疗前F=688.305,P=0.000<0.01,组间计量F=7.879,P=0.000<0.01;CRP:F=11.087,P=0.367>0.05,治疗前F=1059.92,P=0.000<0.01,组间统计量F=22.030,P=0.000<0.01).结论:饮食疗法联合药物治疗的治疗效果要优于单纯的药物治疗和单纯饮食疗法.

AIM：To evaluate the clinical efficacy of diet therapy combined with basic therapy（oral probiotics and Etiasa gas enema） for ulcerative colitis（UC）.METHODS：Ninety patients with moderate or mild to moderate UC were randomly divided into an experimental group,a control group and a blank group.The experimental group and control group were given oral probiotics and Etiasa gas enema.The experimental group and blank group received diet therapy.Inflammatory indicators[leukocytes,erythrocyte sedimentation rate（ESR）,and C-reactive protein]indicators were compared between different groups before and after treatments.RESULTS：The remission rate in the experimental group was higher than those in the control group and blank group（90%vs 83.3%,80.0%）.Erythrocyte sedimentation rate and C-reactive protein were significantly different between before and after treatment in the three groups,and the experimental group was better than the control group and the blank group（ESR：F = 7.879,P = 0.000 0.01;C-reactive protein：F = 22.030,P = 0.000 0.01）.CONCLUSION：Diet therapy combined with basic therapy is superior to either medical therapy or diet therapy alone in ulcerative colitis.