IFN-γ释放试验与T-SOPT平行对比试验诊断结核的敏感性和特异性分析

Analysis on specificity and sensitivity for diagnosis of tuberculosis using IFN-γrelease assay and T-SOPT payaued contrast test

目的比较不同厂家IFN-γ释放试验诊断试剂盒在临床诊断中的价值,探讨IFN-γ释放试验对临床的指导。方法分别用2个厂家IFN-γ释放试验诊断试剂盒检测临床确诊结核病人,与临床参比试剂盒TSOPT进行平行对比试验。结果与参比产品相比,免疫学方法检测结果与参比试剂没有统计学意义。但对非结核病人,参比试剂阳性预测值较高,临床诊断效果更佳。结论 T-SOPT试验对结核病人诊断结果较准确,可以作为结核病筛查试剂。免疫学法IFN-γ检测试剂盒与T-SOPT有较好的临床相关性,作为筛查试剂,可以满足国内低结核病检出率的现状。

Objective To compare the different manufacturers IFN-γ release assays in clinical diagnostic kits diagnosis explore IFN-y release assays for clinical guidance.Methods Respectively,with two production house IFN-γ release assay diagnostic kit to detect clinically diagnosed TB patients,and clinical reference kit T-SOPT parallel comparison test,analyze the results.Result compared with the reference product,immunological detection of the reference reagent results were not significantly different.For non-AIDS TB,reference reagents,the positive predictive value is higher,better clinical diagnosis.Conclusions T-SOPT test results for a more accurate diagnosis of TB,TB screening can be used as reagents.Immunology France IFN-γ detection kit with T-SOPT have better clinical relevance,as a screening reagent to meet domestic low detection rate of TB status.