DNA-蛋白激酶依赖蛋白激酶催化亚基在鼻咽癌中的表达及意义

The expression and clinical significance of DNA-PKcs in nasopharyngeal carcinoma through hierarchical analysis

目的探讨DNA-蛋白激酶依赖蛋白激酶催化亚基（DNA-PKcs）在鼻咽癌中的表达及其临床意义。方法选取2007年5月~2012年7月于广西壮族自治区人民医院肿瘤中心的83例鼻咽癌患者（鼻咽癌组）和32例鼻咽炎患者（鼻咽炎组）,通过免疫组织化学的研究方法分析DNA-PKcs的表达情况,并通过分层分析的方法评估DNA-PKcs与鼻咽癌临床病理学因素之间的联系,进一步分析DNA-PKcs的表达与鼻咽癌预后之间的相关性。结果鼻咽癌患者DNA-PKcs的表达明显高于鼻咽炎患者,差异有高度统计学意义（P〈0.01）;DNA-PKcs的表达水平与鼻咽癌的病理分型、临床分期、体力量表评分、年龄、性别无关（P〉0.05）;DNA-PKcs的表达水平与鼻咽癌患者的近期疗效无显著相关性（P〉0.05）;DNA-PKcs的表达水平越高,鼻咽癌患者的远期生存时间越长（P〈0.01）。结论 DNA-PKcs在鼻咽癌中高表达可以作为一个鼻咽癌预后的预测指标。

Objective To explore the expression and the clinical significance of DNA-PKcs in nasopharyngeal carcinoma. Methods Diagnostic tissues of 83 nasopharyngeal carcinoma patients（nasopharyngeal carcinoma group） and 32 nasopharyngitis patients（nasopharyngitis group） from Cancer Center of People＇s Hospital of Guangxi Autonomous Region from May 2007 to July 2012 were evaluated retrospectively. The expression of DNA-PKcs was analyzed by immunohistochemical and the relationship between the expression of DNA-PKcs and the clinical pathological factors in nasopharyngeal carcinoma were evaluated through the retrospective study methods. Results The expression of DNA-PKcs existed between nasopharyngeal carcinoma patients and nasopharyngitis patients, and the differences were statistically significant（P〈0.01）. However, there was no relevance between the expression of DNA-PKcs and pathology classification,clinical stage, PS score, age or gender（P〉0.05）. The expression level of DNA-PKcs had no relationship with the recent efficacy of patients with nasopharyngeal carcinoma, and the difference was not statistically significant（P〉0.05）.The long-term survival of patients with nasopharyngeal carcinoma was longer, when the expression level of DNA-PKcs was higher, and the difference was statistically significant（P〈0.01）. Conclusion High expression of DNA-PKcs can be used as a predictor of prognosis in nasopharyngeal carcinoma.