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特发性肺纤维化急性加重16例临床特点分析 被引量：1

Clinical characteristics of acute exacerbation of idiopathic pulmonary fibrosis: an analysis of 16 cases
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摘要 特发性肺纤维化（IPF）是临床最常见的一种特发性间质性肺炎,其组织学和（或）胸部高分辨CT（HRCT）特征性表现为普通型间质性肺炎（UIP）。大多数IPF患者肺功能在数年内逐渐恶化,但一些患者在没有明确诱因下,出现急性呼吸功能恶化被称为特发性肺纤维化急性加重（AEIPF）[1]。AEIPF病因不清,发病时间及病程难以预测、病死率高,早期诊断困难,缺乏有效的治疗措施。
作者 薛洪刚 李尔然 李振华
机构地区 中国医科大学附属第一医院呼吸科 阜新矿业集团总医院
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2015年第11期946-948,共3页 Chinese Journal of Practical Internal Medicine
基金 十二五课题资助项目(2012BAI05B01) 国家自然科学基金(30470766) 辽宁省重点实验室资助项目(2009S105)
关键词 特发性肺纤维化急性加重 诊断 治疗 acute exacerbation of idiopathic pulmonary fibrosis diagnosis therapy
分类号 R563 [医药卫生—呼吸系统]
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参考文献14

  • 1Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALATstatement: idiopathic pulmonary fibrosis: evidence-based guidelinesfor diagnosis and management[J]. Am. J Respir Ccit Care Med, 2011,183(6):788-824.
  • 2Johannson K, Collard HR. Acute Exacerbation of IdiopathicPulmonary Fibrosis: A Proposal[J]. Curr Respir Care Rep, 2013,2(4):233-240.
  • 3Kishaba T, Tamaki H, Shimaoka Y, et al. Staging of acute exacerbationin patients with idiopathic pulmonary fibrosis[j]. Lung, 2014,192(1):141-149.
  • 4Kim DS, Park JH, Park BK, et al. Acute exacerbation of idiopathicpulmonary fibrosis : frequency and clinical features[j]. Eur Respir J;2006,27(1): 143-150.
  • 5Hiwatari N, Shimura S, Takishima T, et al. Bronchoalveolar lavage as apossible cause of acute exacerbation in idiopathic pulmonary fibrosispatients [J]. TohokuJ Exp Med, 1994; 174(4): 379-386.
  • 6Sakamoto K, Taniguchi H, Kondoh Y, et al. Acute exacerbation of IPFfollowing diagnostic bronchoalveolar lavage procedures[J].RespirMed, 2012,106(3): 436-442.
  • 7Ushiki A, Yamazaki Y, Hama M, et al. Viral infections in patients withan acute exacerbation of idiopathic interstitial pneumonia[j]. RespirInvestig; 2014,52(1): 65-70.
  • 8Lee JS, Song JW, Wolters PJ, et al.Bronchoalveolar lavage pepsin inacute exacerbation of idiopathic pulmonary fibrosis [j], Eur Respir J,2012,39(2):352-358.
  • 9Song JW, Hong SB, Lim CM, et al. Acute exacerbation of idiopathicpulmonary fibrosis: incidence, risk factors and outcome[j], Eur RespirJ,2011; 37(2): 356-363.
  • 10Ohshimo S, Ishikawa N, Horimasu Y, et al. Baseline KL-6 predictsincreased risk for acute exacerbation of idiopathic pulmonaryfibrosis[J]. Respir Med, 2014,108(7): 1031-1039.

二级参考文献61

  • 1张德平,侯杰.对特发性肺纤维化急性加重的新认识[J].中华结核和呼吸杂志,2007,30(4):298-300. 被引量：11
  • 2Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ ALAT statement: idiopathic pulmonary fibrosis : evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med,2011,183 :788-824.
  • 3Kondoh Y, Taniguchi H, Kawabata Y, et al. Acute exacerbation in idiopathic pulmonary fibrosis. Analysis of clinical and pathologic findings in three cases. Chest, 1993,103 : 1808-1812.
  • 4Akim M, Hamada H, Sakatani M, et al. CT findings during phase of accelerated deterioration in patients with idiopathic pulmonary fibrosis. AJR Am J Roentgenol, 1997,168:79-83.
  • 5Collard HR, Moore BB, Flaherty KR, et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med, 2007, 176:636-643.
  • 6Song JW, Hong SB, Lim CM, et al. Acute exacerbation of idiopathic pulmonary fibrosis:incidence, risk factors and outcome. Eur Respir J,2011,37:356-363.
  • 7Akira M, Kozuka T, Yamamoto S, et al. Computed tomography findings in acute exacerbation of idiopathic pulmonary fibrosis. Am JRespir Crit Care Med,2008,178:372-378.
  • 8Kim DS,Park JH, Park BK, et al. Acute exacerbation of idiopathic pulmonary fibrosis:frequency and clinical features. Eur Respir J, 2006,27 : 143-150.
  • 9Kondoh Y, Taniguchi H, Kitaichi M, et al. Acute exacerbation of interstitial pneumonia following surgical lung biopsy. Respir Med, 2006,100 : 1753-1759.
  • 10Hiwatari N, Shimura S, Takishima T, et al. Bronchoalveolar lavage as a possible cause of acute exacerbation in idiopathic pulmonary fibrosis patients. Tohoku J Exp Med, 1994,174:379-386.

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中国实用内科杂志
2015年 第11期

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