全反式维甲酸联合VADT方案治疗多发性骨髓瘤临床疗效观察
Effectiveness of all-trans retinoic acid combining VADT profile for the treatment of multiple myeloma
摘要
对于全反式维甲酸（ATRA）用于多发性骨髓瘤（multiple myeloma,MM）的治疗尚存争议,争议的焦点为ATRA是否为提高化疗疗效或诱导耐药[1-2]。鉴于热休克蛋白（HSP）在MM中过度表达并与耐药有关,且ATRA可上调成骨细胞转化生长因子-β导致HSP27的蓄积及水平上升[3-7]。有鉴于此,本研究通过MM治疗前后HSP27、RARα2基因的表达及临床指标评估以探讨ATRA对MM的疗效及潜在机制。
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2015年第11期948-950,共3页
Chinese Journal of Practical Internal Medicine
基金
贵州省科技厅联合基金(黔科合SY[2010]3127号)
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