肝硬化患者小肠细菌过度增长情况临床研究

The Clinical Study on Small Intestinal Bacteria Overgrowth in Patients With Hepatic Cirrhosis

目的探讨不同肝功能分级及不同并发症肝硬化患者小肠细菌过增长(SIBO)的情况。方法选取肝硬化患者125例,健康体检者40例,全部行乳果糖氢呼气试验,记录结果并总结分析。结果患者与健康对照组SIBO阳性率比较有差异,且随着肝功能分级SIBO阳性率逐渐升高。无并发症的肝硬化患者其SIBO阳性率低于有并发症的患者,P<0.05,差异具有统计学意义。结论 SIBO发生率与肝功能ChildPugh分级有关,且分级越高SIBO阳性率越高;SIBO与腹水、肝性脑病、上消化道出血有密切的关系。

Objective To explore the situation of SIBO by different child-pugh gradesand complications of hepatic cirrhosis.Methods Selected 125 patients with hepatic cirrhosis and 40 healthy were chosen to examine by lactulose hydrogen breath test and analyze the records.ResultsThe difference of positive rate of SIBO betweenhepatic cirrhosis group and healthy group was statisticallysignificant. The positive rate of SIBO was increase by child-pugh grades. The positive rate of SIBO of patients without complication was lower than the patients with complications,P〈0.05, had difference statistically signiifcance.ConclusionTheincidence rate of SIBO was related to child-pugh grade and the rate increased with the grade. SIBO has afifnity with ascites, hepatic encephalopathyand upper gastrointestinal haemorrhage.