替吉奥同步三维适形放疗治疗老年直肠癌的临床观察

Clinical Observation on Tegafur Synchronous Three-dimensional Conformal Radiotherapy in Treatment of Elderly Patients With Rectal Cancer

目的研究替吉奥同步三维适形放疗治疗老年直肠癌的临床疗效。方法抽取2013年2月-2014年5月我院收治的老年结肠癌患者98例,按照随机数字表法分为对照组和观察组,各49例。均进行三维适形放疗,观察组加用替吉奥早晚口服化疗,治疗2个月后观察对比两组患者治疗疗效及不良反应情况。结果观察组治疗结束后有效率79.6%高于对照组51.0%,P〈0.05,差异具有统计学意义;观察组治疗后胃肠道反应发生率65.3%,高于对照组42.9%,P〈0.05,差异具有统计学意义;观察组骨髓抑制发生率63.3%,对照组42.9%,P〈0.05,差异具有统计学意义;观察组放射性食管炎发生率为53.1%,对照组51.0%,P〉0.05,差异不具有统计学意义。结论替吉奥同步三维适形放疗治疗老年直肠癌疗效好,安全性高。

Objective To study the clinical effect of tegafur synchronous three-dimensional conformal radiotherapy in treating elderly patients with rectal cancer.MethodsSelected 98 cases of elderly patients with rectal cancer from February 2013 to May 2014 in our hospital, were divided into the control group and the observation group, each group had 49 cases, according to the random number table method, all the patients received three dimensional conformal radiotherapy and the observation group were additionally treated with tegafur in the morning and at night for oral chemotherapy. After 2 months of treatment, the treatment effect and adverse reactions of the two groups were observed and compared.Results In the observation group, the efifciency after the end of the treatment was 79.6% higher than 51.0% of the control group ,P〈0.05, had difference statistically significance, After the treatment, the incidence rate of gastrointestinal reactions in the observation group was 65.3% higher than 42.9% of the control group ,P〈0.05, had difference statistically significance, the incidence rate of myelosuppression in the observation group was 63.3% while the control group was 42.9% ,P〈0.05, had difference statistically signiifcance, The incidence rate of radiation esophagitis in the observation group was 53.1% and compared with 51.0% in the control group,P〉0.05, had no difference statistically signiifcance.Conclusion The curative effect of tegafur synchronous three-dimensional conformal radiotherapy in treating elderly patients with rectal cancer is good, with high safety.