观察依帕司他片治疗糖尿病并发周围神经病变的疗效

To Observe the Curative Effect of Epalrestat Tablets in Treatment of Diabetic Peripheral Neuropathy

目的观察分析依帕司他片治疗糖尿病并发周围神经病变的临床疗效。方法将2011年5月-2015年3月自我院进行治疗的糖尿病并发周围神经病变的120例患者作为试验对象,根据随机原则将所有患者分为观察组和对照组,每组60例。观察组在常规维持血糖的治疗同时服用依帕司他片,而对照组在常规治疗基础上给予注射维生素B12,治疗后对比两组患者的临床疗效。结果经过治疗后观察组临床总有效率达到了86.7%,而对照组仅有70.0%,观察组优于对照组,P〈0.05,差异具有统计学意义;且治疗前两组患者神经传导速度相比,P〉0.05,差异不具有统计学意义。治疗后,所有患者传导速度均高于治疗前,且观察组提升程度高于对照组,P〈0.05,差异具有统计学意义。结论对于糖尿病并发周围神经病变采用依帕司他片治疗能够提升临床疗效和神经传导速度。

Objective To observe the clinical effect of Epalrestat Tablets in treating diabetic peripheral neuropathy.MethodsSelected 120 cases of diabetic patients with peripheral neuropathy from May 2011 to March 2015 in our hospital, were randomly divided into the observation group and the control group, each group had 60 cases. the observation group in the routine maintenance for treatment of blood glucose while taking epalrestat company, while the control group in conventional treatment on the basis of given injections of vitamin B12, after treatment, compared two groups of patients with clinical curative effect.ResultsAfter treatment, the observation group clinical total effective rate was 86.7%, and the control group was 70.0%, the observation group was better than the control group, P〈0.05, had difference statistically signiifcance. And compared the nerve conduction velocity of two group,P〉0.05, had no difference statistically signiifcance, after treatment, all patients were higher than before, and the observation group was higher than the control group,P〈0.05, had difference statistically signiifcance.Conclusion For diabetic peripheral neuropathy by epalrestat company tablets in the treatment signiifcantly improved clinical efifcacy and nerve conduction velocity.