摘要
目的探讨急性淋巴细胞性白血病(ALL)患儿应用大剂量甲氨喋呤(HD-MTX)化疗后小剂量四氢叶酸钙(CF)解救的可能性及护理体会。方法将17例确诊急性淋巴细胞性白血病中危型患儿的66例次HD-MTX-CF化疗随机分为观察组和对照组,减少观察组的36例次的HD-MTX化疗后CF的解救剂量至1.5%,对照组的30例次解救剂量仍为常规的3.5%。观察所有患儿的毒副反应,并监测血药浓度。结果对照组的30例化疗中有2例出现口腔黏膜溃烂,3例出现呕吐;观察组的36例化疗中,有2例出现口腔黏膜溃烂,5例出现呕吐,P>0.05,差异不具有统计学意义。结论在严格进行各项护理操作、同时检测MTX血药浓度的情况下,应用小剂量四氢叶酸钙解救急性淋巴细胞性白血病患儿比较安全。
Objective To discuss the possibility of small dose calcium folinate （CF） dealing with the bed effect caused by high dose methotrexate （HD-MTX） treating children with acute lymphoblastic leukemia （ALL） and the nursing care.Methods Selected 17 cases of the ALL patients were treated 66 using HD-MT. The treatments divided into two groups randomly, the observe group had 36 cases and the control group 30 cases. The observe group were given the dose of CF 1.5% after treating by HD-MTX, the control group were given the dose of CF 3.5% after treating by HD-MTX. collected the side effects and monitored the blood concentration.Results There were 5 emesis and 2 oral ulcer of the observe group and 3 emesis and 2 oral ulcer of the control group,P〉0.05, had difference statistically signiifcance.Conclusion It was safe to use small dose CF dealing with the side effect casing by HD-MTX under monitoring MTX blood concentration and nursing carefully.
出处
《中国继续医学教育》
2015年第29期183-184,共2页
China Continuing Medical Education
