中药材中二氧化硫残留量测定方法比较

Comparison of sulfur dioxide residue in Chinese herbal medicines

目的通过3种不同方法对中药材中二氧化硫残留量进行测定,比较分析3种检测方法的有效性及差异。方法采用蒸馏滴定法、酸碱滴定法以及FAIMS技术测定中药材中二氧化硫残留量,并进行统计学分析。结果对3种方法分别进行了方法学验证,其重复性和回收率均能达到检测要求。经统计分析,3种方法测得的结果之间有较高的相关性,均有统计学意义。FAIMS技术测得结果较高,分析可能与其碱液提取方法有关。结论 3种方法均可作为硫熏中药材及饮片二氧化硫残留量测定的有效方法。

Objective To determine sulfur dioxide residue in Chinese herbal medicines by 3 methods, and analyze the availability and difference of the 3 methods. Methods The amounts of sulfur dioxide residue in Chinese herbal medi- cines were determined by iodine titration method, alkali titration method and high-field asymmetric waveform ion mobility spectrometry （FAIMS）. The results were analyzed. Results The methodology of these 3 methods was vali- date. Both the repeatability and recovery met the requirements of detection. There was a high correlation between the measured results. The result from FAIMS was higher, and the possible reason was that the solution was extracted by alkali. Conclusion These 3 methods are effective in determining sulfur dioxide residue in Chinese herbal medicines.