加味阳和汤治疗乳腺癌骨转移的临床观察

Clinical observation of supplemented Yanghe decoction on the treatment of bone metastasis of breast cancer

目的观察加味阳和汤治疗乳腺癌骨转移的临床疗效。方法选取2013年3月~2015年3月在本院治疗的乳腺癌骨转移患者60例,随机平均分为2组,试验组的30例患者使用口服加味阳和汤加减联合静脉滴注唑来膦酸治疗,对照组的30例患者仅使用唑来膦酸治疗,从治疗后骨转移灶、活动能力、生活质量、疼痛情况及高钙血症和碱性磷酸酶的改善情况比较2组临床疗效。结果 1试验组在改善骨转移灶方面有效率高于对照组,但差异无统计学意义（P〉0.05）;2试验组活动能力、生活质量卡氏评分、疼痛评分改善情况优于对照组（P〈0.05）;3试验组高钙血症及AKP改善情况优于对照组,但差异无统计学意义（P〉0.05）。结论加味阳和汤治疗乳腺癌骨转移有较好的临床疗效,值得推广应用。

Objective To observe the clinical effect of supplemented Yanghe decoction for bone metastases of breast cancer. Methods Between March 2013 and March 2015, 60 patients with bone metastases of breast cancer in our hospital were randomly assigned to 2 groups： the test group （30 patients） had oral supplemented Yanghe decoction combined with Zoledronic acid injection, while the control group （30 patients） had Zoledronic acid treatment alone. The clinical effect of the 2 groups after the treatment was compared improvements in bone metastastic focus, mobility, quality of life, pain and hypercalcemia and alkaline phosphatase. Results① The improvement in bone metastastic focus had higher efficiency in the test group than that in the control group, without significant difference （P 〉 0.05）; ② Mobility, improving KPS, and pain score in the test group were better than those in the control group （P 〈 0.05）; ③ The test group had improved hypercalcemia and AKP compared with the control group, without difference （P 〉 0.05）. Conclusion Supplemented Yanghe decoction is effective in for breast cancer with bone metastasis.