IL-17＋Foxp3＋T细胞的研究进展被引量：2

Research progress of IL-17^+Foxp3^+T cells

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摘要近来有文献报道复杂的细胞因子环境下,调节性T细胞(regulatory T cells,Tregs)可以转变为表型和功能上酷似Th17的新的T细胞亚群,即白细胞介素(IL)-17+Foxp3+T细胞。IL-17^+Foxp3^+T细胞分泌IL-17并表达维甲酸受体相关孤儿受体γt(RORγt),在免疫系统中表现出双重特性。IL-17^+Foxp3^+T细胞的发现为理解Tregs和Th17的关系提供了新的思路。本文重点介绍了IL-17^+Foxp3^+T细胞的表型特征、分化来源和多效性功能,并进一步总结了炎症性疾病和肿瘤微环境中IL-17^+Foxp3^+T细胞的作用。 Recently, it is reported that regulatory T cells （Tregs） can be reprogrammed into a novel population [interleu-kin （IL）-17＋Foxp3＋T cells] phenotypically and functionally resembling Th17 cells under complicated cytokine circumstanc-es. IL-17＋Foxp3＋T cells are characterized by production of IL-17 and expression of retinoic acid receptor related orphan re-ceptor （ROR）γt, demonstrating dual functions in immune response and providing novel insight into the interconnection be-tween Tregs and Th17 cells. In this review, we lay emphasis on the phenotype features, origination, differentiation and the pleiotropic functions of IL-17＋Foxp3＋T cells. Furthermore, we summarized the functions of IL-17＋Foxp3＋T cells in inflam-matory disease and tumor microenvironment.

作者赵华李慧任秀宝

机构地区天津医科大学肿瘤医院免疫室

出处《天津医药》 CAS 2015年第11期1342-1344,共3页 Tianjin Medical Journal

基金国家自然科学基金资助项目(81401888) 天津市应用基础与前沿技术研究计划项目(13JCQNJC10400)

关键词 T淋巴细胞调节性白细胞介素17 炎症肿瘤综述 IL-17+’Foxp3+T细胞维甲酸受体相关孤儿受体γt T-lymphocytes,regulatory inflammation neoplasms review IL-17 ＋ Foxp3 ＋ T cells RORγt

分类号 R392 [医药卫生—免疫学]

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