亚临床甲状腺功能减退与自然流产相关性研究

Research of correlation between subclinical hypothyroidism and spontaneous abortion

目的探讨亚临床甲状腺功能减退与自然流产的相关性,以避免反复流产的发生,提高正常妊娠率。方法 150例早孕妇女作为研究对象,有2次及2次以上自然流产史为A组,1次自然流产史为B组,无不良孕史为C组,各50例。用电化学发光法检测并比较促甲状腺素(TSH)和游离甲状腺素(FT4)。结果亚临床甲状腺功能减退患病率A组28.00%,B组22.00%,C组6.00%。A组与B组比较,差异无统计学意义(P>0.05);A组与C组、B组与C组比较,差异均有统计学意义(P<0.05)。结论亚临床甲状腺功能减退与自然流产有明显相关性,与自然流产次数无明显相关性,对于有不良孕史早孕妇女应常规筛查并尽早积极治疗。

Objective To investigate correlation between subclinical hypothyroidism and spontaneous abortion, in order to avoid recurrent abortion and to improve rate of normal pregnancy. Methods There were 150 early pregnancy women as study subjects. Group A contained patients with twice or more spontaneous abortion, group B contained patients with once spontaneous abortion, group C contained patients without bad pregnancy history, and each group contained 50 cases. Electrochemiluminescence was applied to compare thyroid stimulating hormone （TSH） and free thyroxine （FT4）. Results Subclinical hypothyroidism accounted for 28.00% in group A, 22.00% in group B and 6.00% in group C. There was no statistically significant difference between group A and group B （P〉0.05）. The differences between group A and group B, group A and group C all had statistical significance （P〈0.05）. Conclusion There is an obvious correlation between subclinical hypothyroidism and spontaneous abortion, while subclinical hypothyroidism is not correlated with time of spontaneous abortion. Conventional screening and timely treatment are necessary for early pregnancy women with bad pregnancy history.