莫西沙星注射液治疗下呼吸道感染的有效性及安全性分析

Analysis of the efficacy and safety of moxifloxacin in the treatment of lower respiratory infection

目的观察莫西沙星注射液治疗下呼吸道感染的临床疗效及安全性。方法将103例下呼吸道感染患者采用随机数字表法分为观察组52例和对照组51例，对照组患者给以左氧氟沙星注射液5g溶人5％葡萄糖100ml静脉滴注，1次，d，观察组以莫西沙星注射液静滴给药4g／次，1次／d，两组给药疗程为5～14d，评估临床疗效及不良反应。结果观察组总有效率为92．30％，细菌清除率为95．12％，明显高于对照组的74．50％和76．19％，组问比较差异有统计学意义（X2=4．697、4．579，P〈0．05）。观察组总治疗时间为（7．06±2．13）d，明显短于对照组（9．10±1．89）d，差异有统计学意义（t=5．137，P〈0．05）。结论莫西沙星注射液治疗下呼吸道感染疗效确切，且具有良好的安全性。

Objective To observe therapeutic efficacy and safety of moxifloxacin in the treatment of lower respiratory infection. Methods 103 cases of lower respiratory infection were divided into observation group （n=52） and control group （n=51） with the random number table method. Control group was given intravenous drip oflevofloxacin injection 5 g added into 100 ml 5% glucose injection once a day, while observation group was given intravenous drip of moxifloxacin injection 4 g added into 100 ml 0.9% physiological saline injection once a day. Treatment course of 2 groups lasted for 5-14 days. The clinical efficacy and adverse reactions were analyzed. Results The total effective rate was 92.30%, and the bacterial clearance rate was 95.12% in observation group, while those in control group were 74.50% and 76.19%, with statistically significant differences between two groups （X2=4.697, 4.579; P〈0.05）. The treatmenttime of observation group was （7.06±2.13）d, significantly shorter than （9.10±1.89）d of control group, with statistically significant difference between two groups （t=5.137, P〈O.05）. Conclusion Moxifloxacin injection in the treatment of lower respiratory infection has curative effect and safety.