摘要
以2-(4-溴苯基)-2-甲基丙酸为原料,经羧基保护,与γ-丁基内酯反应,经磺酰化、缩合、还原、脱保护,最终制得标题化合物,总收率56.4%。该工艺原料价廉易得,操作简单,后处理容易,副产物较少。
Starting with 2-（ 4-bromine phenyl）-2-methyl propionic acid,Fexofenadine hydrochloride was synthesized via six steps reaction such as carboxyl protection,reaction with γ-butyrolactone,sulfonylation,condensation,reduction,deprotection. The overall yield was 56. 4%. The method of preparation is performed with cheap raw materials,simple operation,and fewer by-products.
出处
《化学试剂》
CAS
北大核心
2015年第11期1054-1056,共3页
Chemical Reagents
