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MicroRNA-7在DNA损伤修复中研究进展 被引量：3

Research progress of microRNA-7 in DNA damage repair
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摘要 微小RNA（microRNA,miRNA）是一类存在于真核生物中的非编码小RNA,由大小约19~24个核苷酸组成,通过结合在靶基因mRNA的3＇非编码区,降低mRNA稳定性或抑制翻译影响蛋白的表达,在转录后水平参与众多生理病理过程。日常生活和职业环境中有毒有害因素可通过多种途径进入人体产生遗传毒性,直接或间接引起DNA损伤。
作者 陈玉婷 云林 徐龙妹 刘嘉贤 唐焕文
机构地区 广东医学院公共卫生学院 广东医学院环境与健康研究所 东莞市环境医学重点实验室
出处 《中国职业医学》 CAS 北大核心 2015年第5期575-578,共4页 China Occupational Medicine
基金 国家自然科学基金(81273116) 广东省自然科学基金(S2013010015153) 湛江市科技计划项目(2013B01082) 广东医学院科研基金(XK1414)
关键词 microRNA-7 细胞周期 DNA损伤修复 细胞凋亡 肿瘤
分类号 R73 [医药卫生—肿瘤]
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参考文献29

  • 1Farazi TA,Spitzer JI,Morozov P,et al.miRNAs in human cancer[J].J Pathol,2011,223(2):102-115.
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二级参考文献14

  • 1王旭丹,杨惠玲,郭禹标,梁志慧,赵睿颖,夏云飞,苏勇,Mong-Hong Lee,王瑾,郑芹.不同辐射抗拒鼻咽癌细胞微小RNA差异表达的研究[J].中国病理生理杂志,2007,23(6):1045-1048. 被引量：25
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  • 9Xu Y, Shao Y, Zhou J, et al. Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear transiocation in human keratinocytes [ J ]. J Cell Biochem, 2009, 107(5): 873-80.
  • 10Sehmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method[J]. Nat Protoc, 2008, 3(6): 1101-8.

共引文献11

同被引文献17

引证文献3

二级引证文献13

中国职业医学
2015年 第5期

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