CD24在结直肠癌中的表达及其意义

Expression and significance of CD24 in colorectal cancer

目的 检测CD24在结直肠癌等组织中的表达,探讨CD24与结直肠癌临床病理特征的关系.方法 采用免疫组织化学法对62例结直肠癌、47例腺瘤、15例息肉以及30例正常结直肠黏膜石蜡切片进行CD24表达的检测,分析CD24的表达与临床病理特征的关系.结果结直肠癌（72.6％）及腺瘤（63.8％） CD24阳性表达率均明显高于结直肠增生性息肉13.3％（x2=17.83,P=0.00;x2=11.61,P=0.00）、正常黏膜6.7％（x2=35.15,P=0.00;x2 =24.64,P=0.00）.CD24与结直肠癌直径（x2=5.48,P=0.02）、分化程度（x2=8.86,P=0.00）、Duke分期（x2=11.47,P=0.00）、淋巴结转移（x2=8.92,P=0.00）相关.结论 CD24在结直肠癌中高表达,且与结直肠癌直径、分化程度、Duke分期、淋巴结转移有关.

Objective To determine the expression of CD24 in colorectal carcinoma, and to explore the relationship between CD24 and the clinicopathological features of colorectal carcinoma.Methods The expression of CD24 in 62 cases of colorectal carcinoma, 47 cases of adenomas, 15 cases of colorectal polyps and 30 cases of the adjacent non-cancerous tissues were observed by immunohistochemical assay.The relationship between CD24 and the clinicopathological features was analyzed.Results The positive rates of CD24 in colorectal carcinoma 72.6% and adenomas 63.8% were significantly higher than those in colorectal hyperplastic polyps 13.3% （x2 =17.83, P =0.00;x2 =11.61, P =0.00） and adjacent non-cancerous tissues 6.7% （x2 =35.15, P =0.00;x2 =24.64, P =0.00）.The expression of CD24 in colorectal carcinoma had a significant correlation with the tumor diameter （x2 =5.48, P =0.02）, tumor differentiation （x2 =8.86, P =0.00）, Duke staging （x2 =11.47, P =0.00） and lymph node metastasis （x2 =8.92, P =0.00）.Conclusion The expression of CD24 is high in colorectal carcinoma, having a significant correlation with the size of tumor, degree of differentiation, Duke stage and lymph node metastasis.