Yes相关蛋白在子宫内膜癌中的表达及临床病理意义

Expression and clinicopathological significance of Yes-associated protein in endometrial cancer

目的 探讨Yes相关蛋白（YAP）在子宫内膜癌中的表达及其临床病理意义.方法 免疫组织化学MaxVisionTM法检测289例子宫内膜癌患者组织中YAP表达水平,分析其与患者临床病理特征及预后的关系.结果 YAP在Ⅱ型子宫内膜癌中的表达率高于Ⅰ型子宫内膜癌（87.0％：55.1％ ,x2=16.340,P＜0.001）.在Ⅰ型子宫内膜癌中,YAP在组织学分级G1中的表达率为51.6％,低于G2-G3中的表达率80.0％ （x2 =8.549,P =0.005）.YAP表达与绝经状态（x2=0.045,P=0.831）、FIGO分期（x2=0.976,P=0.323）、淋巴血管间隙浸润（x2=0.000,P=1.000）、淋巴结转移（x2=0.976,P =0.323）和ER状态（x2=3.318,P=0.069）无关;在Ⅱ型子宫内膜癌中,YAP表达与绝经状态（x2=0.305,P=0.581）、FIGO分期（x2=2.395,P=0.122）、淋巴血管间隙浸润（x2=1.441,P=0.230）、淋巴结转移（x2=1.351,P=0.245）和ER状态（x2=0.000,P=1.000）无关.在Ⅰ型子宫内膜癌中,Log-rank检验分析显示高表达YAP的患者整体生存率较低（x2=14.023,P＜0.001）,但不是独立的预后因子.结论 YAP在子宫内膜癌中具有较高的表达率.在Ⅰ型子宫内膜癌中,YAP表达与组织学分级及预后正相关.

Objective To study the expression of Yes-associated protein（YAP） in endometrial cancer and its clinical pathological significance.Methods Immunohistochemieal MaxVisionTM method was used to detect the expression of YAP in 289 cases of endometrial cancer, and its relationship with clinical pathological features and prognosis were analyzed.Results The expression rate of YAP in type Ⅱ endometrial cancer was higher than that in typeⅠendometrial cancer （87.0% vs.55.1%, x2 =16.340, P 〈 0.001）.In typeⅠendometrial cancer, the expression rate of YAP in G1 cases was lower than that in G2-G3 cases （51.6% vs.80.0%, x2 =8.549, P =0.005）, not associated with menopausal status （x2 =0.045, P =0.831）, FIGO stage （x2 =0.976, P =0.323）, lymph vascular space invasion （x2 =0.000, P =1.000）, lymph node metastasis （x2 =0.976, P =0.323） and ER status （x2 =3.318, P =0.069）.In typeⅡendometrial cancer, the expression of YAP was not significantly associated with menopausal status （x2 =0.305, P =0.581）, FIGO stage （x2 =2.395, P =0.122）, lymph vascular space invasion （x2 =1.441, P =0.230）, lymph node metastasis （x2 =1.351, P =0.245） and ER status （x2 =0.000, P =1.000）.Log-rank test analysis showed that YAP high-expression was associated with a significantly worse overall survival in typeⅠ endometrial cancer （x2 =14.023, P 〈 0.001）, but YAP expression was not an independent prognostic factor.Conclusion YAP shows high expression in endometrial cancer.It is associated with histological grade and prognosis of typeⅠ endometrial cancer.