期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基质金属蛋白酶-9在转移性乳腺癌中的研究现状

Research status of matrix metalloproteinase-9 on metastatic breast cancer
原文传递
导出
摘要 基质金属蛋白酶-9 （MMP-9）通过多种机制促进乳腺癌的侵袭、转移,其在乳腺癌患者体内的表达程度与预后存在一定的相关性.MMP-9表达水平越高,预后可能越差.检测乳腺癌患者治疗前后体内MMP-9表达水平的变化,可作为乳腺癌预后及治疗疗效的一种参考指标. Matrix metalloproteinase-9 （MMP-9） can promote the invasion and metastasis of breast cancer through various mechanisms.The expressions of MMP-9 in the patients with breast cancer are correlated with the prognosis.The higher expression of MMP-9 indicates poorer prognosis.It is suggested that the level change of MMP-9 pre and post treatment can be used as a reference standard for judging the prognosis and clinical effect.
作者 李莉 孙蔚莉 刘德林 武渊 王友群
机构地区 中国药科大学临床药学教研室 江苏省肿瘤医院肿瘤内科
出处 《国际肿瘤学杂志》 CAS 2015年第11期845-848,共4页 Journal of International Oncology
基金 江苏省肿瘤医院科研基金（ZM201204）
关键词 基质金属蛋白酶9 乳腺肿瘤 预后 参考标准 Breast neoplasms Prognosis Reference standards
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献27

  • 1邵彬,李惠平,朱军,邸立军,宋国红,姜晗昉,梁旭,王超颖,严颖,林晓琳,王丽娜,宛凤玲,袁艳华,尤渺宁.复发转移性乳腺癌患者血浆miRNA表达水平与临床病理特征、化疗疗效及预后关系的研究[J].癌症进展,2015,13(2):106-113. 被引量：13
  • 2Chia CY, Kumari U, Casey PJ. Breast cancer cell invasion mediated by Gotl2 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2[ J]. J Mol Signal, 2014, 9: 6.
  • 3Batra J, Robinson J, Mehner C, et al. PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-I ( TIMP-I ) [ J ]. PLoS One, 2012, 7 ( 11 ) : e50028.
  • 4Martin MD, Carter K J, Jean-Philippe SR, et al. Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background [ J]. Cancer Res, 2008, 68 ( 15 ) : 625145259.
  • 5Mehner C, Hoekla A, Miller E, et al. Tumor cell-produced matrix metallo proteinase-9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer[J]. Oncotarget, 2014, 5 (9) : 2736-2749.
  • 6武渊,唐金海,孙蔚莉.乳腺癌抗血管生成治疗的研究进展[J].临床肿瘤学杂志,2010,15(5):465-471. 被引量：5
  • 7Dedes PG, Cialeli Ch, Tsonis A1, et al. Expression of matrix macro-molecules and functional properties of breast cancer cells are modula- ted by the bisphosphonate zoledronic acid [ J ]. Biochim Biophys Acta, 2012, 1820(12) : 1926-1939.
  • 8Christofersson G, Vagesjo E, Vandooren J, et al. VEGF-A recruits a proangiogenic MMP-9-delivefing neutrophil subset that induces angiogenesis in transplanted hypoxic tissue [ J ]. Blood, 2012, 120 (23) : 4653-4662.
  • 9Tang L, Ma X, Tian Q, et al. Inhibition of angiogenesis and invasion by DMBT is mediated by downregulation of VEGF and MMP-9 through Akt pathway in MDA-MB-231 breast cancer ceils [ J]. Food Chem Toxicol, 2013, 56: 204-213.
  • 10Deryugina EI, Quigley JP. Tumor angiogenesis: MMP-mediated in- duction of intravasation- and neovasculature [J]. Matrix Biol, 2015, 44-46: 94-112.

二级参考文献168

  • 1汤坚强,万远廉,刘玉村,戎龙,汪欣,吴涛,潘义生,叶京明,姚宏伟,朱静.组织因子促进人类大肠癌细胞的侵袭及与基质金属蛋白酶类的相关性研究[J].北京大学学报（医学版）,2005,37(3):265-268. 被引量：13
  • 2邓君,杨洋.细胞角蛋白19基因表达及其他肿瘤标志物在乳腺癌诊断中的应用[J].国外医学（临床生物化学与检验学分册）,2005,26(7):390-392. 被引量：6
  • 3王新友,王岭,陈江浩,姚青,易军,王辉.CEF方案新辅助化疗对乳腺癌患者血浆基质金属蛋白酶-2,-9活性的影响[J].中国现代医学杂志,2006,16(18):2741-2743. 被引量：3
  • 4[1]Motowo N,Welch D R,Wynn D M,et al.Serum and plasma Mr 92,000 progelatinase levels correlate with spontaneous metastasis of rat 13762NF mammary adenocarcinoma[J].Cancer Research,1993,53:5802-5807.
  • 5[2]Zucker S,Lysik R M,Zarrabi M H,et al.Mr 92,000 type Ⅳ collagenase is increased in plasma of patients with colon cancer and breast cancer[J].Cancer Research,1993,53:140-146.
  • 6[3]Remacie A G,Noel A,Duggan C,et al.Assay of matrix metalloproteinases types 1,2,3 and 9 in breast cancer[J].British J Cancer,1998,77:926-931.
  • 7[4]Scorilas A,Karameris A,Arnogiannak N,et al.Overexpression of matrix-metalloproteinase-9 in human breast cancer:a potential favourable indicator in node-negative patients[J].British J Cancer,2001,84:1488-1496.
  • 8[5]Moses M A,Wiederschain D,Loughlin K R,et al.Increased incidence of matrix matalloproteinases in urine of cancer patients[J].Cancer Research,1998,58:1395-1399.
  • 9[6]Li Y,Borregaard N,Kjeldsen L,et al.The high molecular weight urinary matrix metalloproteinase(MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin(NGAL)[J].J Biol Chem,2001,276:37258-37265.
  • 10[7]Curran S,Murray G I.Matrix metalloproteinases:molacular aspects of their roles in tumour invasion and metastasis[J].European J Cancer,2000,36:1621-1630.

共引文献41

国际肿瘤学杂志
2015年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部