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miR-375在消化系统肿瘤中的表达及作用

Expression and role of miRNA-375 in digestive system tumors
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摘要 微小RNA通过调节基因转录后水平的表达在生物学过程发挥重要作用.越来越多的研究发现miR-375在消化系肿瘤中普遍低表达,与肿瘤的发生有关.过表达的miR-375可通过抑制靶基因的表达起到抑制肿瘤生长、转移的作用. micmRNA （miRNA） plays an important role in biological processes via regulating gene expression in the level of posttranscription.Increasing number of studies reveal that miR-375 is downregulated in digestive system tumors, and is related to tumorigenesis.Overexpression of miR-375 can inhibit growth and metastasis of tumors through repressing the expression of target genes.
作者 陈征 刘晓峰 董倩倩 麻树霖
机构地区 济南军区总医院消化内科
出处 《国际肿瘤学杂志》 CAS 2015年第11期863-865,共3页 Journal of International Oncology
关键词 消化系统肿瘤 肿瘤转移 微RNAs MicroRNAs Digestive system neoplasms Neoplasm metastasis
分类号 R735 [医药卫生—肿瘤]
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参考文献26

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国际肿瘤学杂志
2015年 第11期

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