神经周围浸润的发生机制及对早期宫颈癌的影响

Mechanisms of perineural invasion and its effect on early cervical cancer

神经周围浸润（PNI）发生的机制可能有：微环境的影响,癌细胞与神经之间的相互作用,基质细胞的作用,癌细胞自身的作用,神经营养因子与受体及趋化因子与受体参与的癌细胞与神经组织间的信号转导.其对早期宫颈癌在手术方式、辅助治疗、预后等方面产生影响.

Mechanisms of perineural invasion may include the effect of microenvironment, the interaction of cancer cell and nerve, the action of stromal cell and cancer cell, signal transduction between the cancer cell and nerve by the involvement of the neurotrophin and its receptor, chemokines and its receptor.Its impacts on early cervical cancer include surgery, adjuvant therapy, prognosis and so on.