卵巢型子宫内膜异位症的临床病理特征与预后的相关性

Correlation between Clinicopathological Features and Prognosis in the Ovarian Endometriosis

目的：探讨卵巢型子宫内膜异位症的临床病理特征与预后的相关性。方法：选取2013年6月-2014年6月期间在我院住院行腹腔镜手术、病理确诊的卵巢型子宫内膜异位症患者60例作为观察组,同期选择确珍为非子宫内膜异位症的卵巢良性肿瘤患者60例为对照组,两组都进行骨桥蛋白的免疫组化分析、病理特征与预后情况调查,并进行相关性分析。结果：观察组的组织学分型、疾病分期和分化程度与对照组对比差异有统计学意义（P〈0.05）。OPN在观察组中的阳性表达率分别为56.7%,在对照组中的阳性表达率分别为83.3%,对比差异都有统计学意义（P〈0.05）。观察组与对照组的1年生存率分别为96.7%和85.0%,观察组1年生存率明显高于对照组（P〈0.05）。Pearson直线相关分析显示卵巢型子宫内膜异位症患者的组织学分型、疾病分期、分化程度和OPN阳性表达与1年生存率呈现明显相关性（P〈0.05）。结论：卵巢型子宫内膜异位症的临床病理特征多表现为透明细胞肿瘤、FIGOⅠ期与高分化状态,OPN呈现相对低表达状况,预后生存率比较高,且临床病理特征与预后有一定的相关性。

Objective： To investigate the correlation between clinicopathological features and prognosis in the ovarian endometriosis. Methods ： From June 2013 to June 2014 in our hospital, selected 60 ovarian endometriosis patients with pathologically confirmed as the observation group,and selected non endometriosis benign ovarian disease 60 patient as the control group, two groups were carried osteopontin immunohistochemical analysis and pathological features and prognosis surveys,and were given the correlation analysis.Results：The histological type,staging and differentiation compared the difference in the two groups were statistically significant difference（P〈0.05）.The OPN positive expression rates in the observation group and the control group were 56.7 % and 83.3% respectively that compared to the differences were statistically significant（P〈0.05）.The 1-year survival rates in the observation group and the control group were 96.7% and 85.0% that the 1 year survival rate of the observation group was significantly higher（P〈0.05）.Pearson linear correlation analysis showed that the ovarian endometriosis patients with histological type,stage of disease,differentiation and expression of OPN and 1-year survival rates were showed significant correlation（P〈0.05）.Conclusion：The ovarian endometriosis clinicopathological features is more performance for clear cell tumors,FIGOⅠ and scores state,OPN exhibit relatively low expression levels,the prognosis is relatively high survival rate,and the clinical pathological features is correlated to the prognosis.