不同序贯放化疗方案对广泛期小细胞肺癌患者生存时间及胸内复发率的影响

Effects of Different Sequential Radiotherapy and Chemotherapy on the Recurrence Rate of Extensive Stage Small Cell Lung Cancer Patients Survival Time and Internal Thoracic

目的：探讨不同序贯放射治疗、化学治疗（放化疗）方案对广泛期小细胞肺癌患者生存时间及胸内复发率的影响。方法：从本院2011年2月-2013年2月收治的广泛期小细胞肺癌患者中随机选择40例进行研究,随机分为两组,分别给予不同的序贯放化疗方案进行治疗。观察两组的生存时间及胸内复发情况,并进行比较。结果：对两组患者的各项临床资料进行比较,差异均无显著性（均P〉0.05）;两组患者的生存时间及胸内复发率经比较均无统计学意义（均P〉0.05）;治疗过程中的主要毒性反应为血液学毒性,经比较,两组患者的毒性反应差异均无统计学意义（均P〉0.05）。结论：采用两种序贯放化疗方案治疗广泛期小细胞肺癌对患者的生存时间及胸内复发率的影响差异不大。

Objective： To explore the influence of different sequential radiotherapy and chemotherapy on survival time and recurrence rate within the chest for patients with extensive stage small cell lung cancer.Methods：40 cases of patients with extensive stage small cell lung cancer in our hospital from February 2011 to February 2013 were selected,and were divided into two groups.All of the patients were given different sequential chemotherapy regimen.The survival time and recurrence rate within the chest of the two groups were observed and compared.Results：The differences of clinical data between the two groups were all not significantly（all P〉0.05）.The differences of survival time and recurrence rate within the chest between the two groups were all not significantly（all P〉0.05）.The main toxic reaction during the treatment was hematologic toxicity,the differences of toxic reaction between the two groups were all not significantly（all P〉0.05）.Conclusion：The differences of the influence between different sequential radiotherapy and chemotherapy on survival time and recurrence rate within the chest for patients with extensive stage small cell lung cancer is not significantly.