hTERC基因在筛查宫颈病变中的价值

The value of hTERC gene in screening cervical lesions

宫颈癌是引起女性死亡最常见的生殖道恶性肿瘤,作为目前唯一一种可以预防的恶性肿瘤,及时发现并干预癌前病变的进展和演变,可有效阻断宫颈癌的发生。宫颈癌三阶梯筛查已经在国内广泛应用,但有其不足之处。研究发现人类染色体端粒酶RNA基因(位于3q26.3)的异常扩增在宫颈癌的发生发展中起着重要的作用,h TERC基因也许可作为筛查及诊断宫颈病变新手段。

Cervical cancer is the principal cause of mortality due to cancer in women worldwide. Because of the long process,it is very important for timely detection of precancerous lesions and effective intervention to block the occurrence of cervical cancer. The three-step screening,cytology-colposcopy-histology,is widespread used in China,which still have many limitations.It was demonstrated that amplification of the human telomerase RNA gene component（h TERC）gene in 3q26.3 3q26.3is key to cervical cancer progression,hence,h TERC gene may be a marker for screening and diagnosing cervical lesions.