早发型子痫前期患者表皮生长因子、C反应蛋白及D-二聚体水平变化及其临床意义

Early-onset preeclampsia patients epidermal growth factor,C-reactive protein,D-dimer level change and its clinical significance

目的探讨早发型子痫前期(PE)患者血清表皮生长因子(EGF)、C反应蛋白(CRP)及血浆D-二聚体(D-D)的水平变化及其临床意义。方法选取确诊为早发型子痫前期孕妇58例作为观察组,其中轻度早发型子痫前期组34例,重度早发型子痫前期组24例;随机抽取35例同期妊娠结局正常孕妇作为对照组。检测各组患者的血清EGF、CRP及血浆D-D水平,观察EGF、CRP、D-D与早发型子痫前期的关系。结果重度早发型子痫前期组孕妇血清EGF、CRP及血浆D-D水平明显高于轻度早发型子痫前期组及对照组,差异有统计学意义(P<0.05或P<0.01);轻度早发型子痫前期组孕妇血清EGF、CRP及血浆D-D水平明显高于对照组,差异有统计学意义(P<0.05或P<0.01)。早发型子痫前期并发胎儿生长受限(FGR)孕妇血清EGF、CRP及血浆D-D水平明显高于未并发FGR孕妇,差异有统计学意义(P<0.05或P<0.01)。结论孕妇EGF、CRP及D-D水平升高,可能与早发型子痫前期发生、发展和FGR发生有关。

Objective：To investigate the early-onset preeclampsia patients serum epidermal growth factor（EGF）,C-reactive protein（CRP）and plasma D-dimer（D-D） level change and its clinical significance. Methods：Selected diagnosed with early-onset preeclampsia 58 cases as the observation group,Among 24 cases of mild early-onset preeclampsia,34 cases of severe early-onset preeclampsia;Randomly selected 35 cases of normal pregnancy outcomes of pregnant women over the same period as the control group. Detected the level of serum EGF,CRP and plasma DD in each group of patients,observed the relationship between EGF,CRP,D-D and early-onset preeclampsia. Results：Severe early-onset preeclampsia group of pregnant women serum EGF,CRP and plasma D-D levels were significantly higher than mild early-onset preeclampsia group and the control group,the difference was statistically significant（P〈0.05 or P〈0.01）;Mild early-onset preeclampsia group of pregnant women serum EGF,CRP and plasma D-D levels were significantly higher than the control group,the difference was statistically significant（P〈0.05 or P〈0.01）. Early-onset preeclampsia complicated with fetal growth restriction（FGR）in maternal serum EGF,CRP and plasma DD levels were significantly higher in pregnant women is not complicated with FGR,the difference was statistically significant（P〈0.05 or P〈0.01）. Conclusion：Pregnant women of the level of EGF,CRP and D-D elevated,possibly with early-onset preeclampsia occurrence,development and FGR.