“健脑安神”针刺法对失眠患者血清TNF-α、IL-6的影响

Effect of Acupuncture Therapy of Strengthening Brain and Calming Mind on Serum TNF- α and IL- 6 of Insomniacs

目的:探讨"健脑安神"针刺法对失眠患者临床疗效和血清TNF-α、IL-6的影响。方法:选取符合诊断标准的失眠患者36例进行"健脑安神"针刺法治疗,在治疗前后分别检测其匹茨堡睡眠指数积分和血清中TNF-α、IL-6的含量,每日针刺1次,每周5次,10次为1个疗程。结果:治疗2个疗程后,36例中痊愈17例,显效10例,有效6例,无效3例,总有效率为91.67%。治疗前后TNF-α和IL-6差异均P<0.05,表明治疗前后差异有显著意义。结论:"健脑安神"针刺法可以改善患者睡眠质量、升高失眠患者血清IL-6含量、降低TNF-α含量,提示针刺后患者血清IL-6和TNF-α含量发生变化,可能是健脑安神针刺法治疗失眠的作用机制之一。

Objective： To observe the effect of acupuncture therapy of strengthening brain and calming mind on clinical efficacy and serum TNF- αand IL- 6 in patients with insomnia. Methods： 36 cases definitely diagnosed with insomnia were treated by the acupuncture therapy of strengthening brain and calming mind,and Pittsburgh Sleep Index Point was detected and TNF- α and IL- 6 content in serum were measured before and after treatment. Do acupuncture treatment once a day,5 times a week,10 times as a course of treatment. Results： After two courses of treatment,17 recovered; 10 had a significant effect; 6 were effective; 3 were ineffectiven in 36 cases,and the total efficiency was 91. 67%. Before and after treatment,mean TNF- α and IL- 6 difference,statistically,both P〈0. 05,indicating a significant difference before and after treatment. Conclusion： The acupuncture therapy of strengthening brain and calming mind is effective for treating insomnia,and it can increase IL-6 levels and lower TNF- α levels,indicating that the acupuncture therapy plays a role in TNF- α and IL- 6levels,which may be one of the mechanisms for treating insomnia.