高通量血液透析对尿毒症患者瘦素及TNF-α的清除和微炎症状态影响

Effect of High Flux Hemodialysis Patients with Uremia Leptin and TNF Alpha Removal and Micro Inflammation State

目的:观察高通量透析对患者瘦素及TNF-α的清除效果。方法:采用前瞻性、自身对照研究。120例维持性低通量血液透析患者转换为高通量血液透析治疗6个月。分别测定高通量透析治疗前(0个月)、治疗后3个月、6个月患者的瘦素、TNF-α水平。结果:高通量透析治疗前(0个月)患者瘦素、TNF-α水平分别为(8.21±4.18)ng/ml、(16.91±6.14)ng/ml,6个月后分别下降为(5.54±3.39)ng/ml、(14.36±2.94)ng/ml,差异有统计学意义(P<0.05)。结论:高通量透析能有效清除患者瘦素及TNF-α,进而较好的改善患者的营养不良状态及微炎症状态,提高患者生活质量。

Objective： To observe the dfeet of Kgh- flux hemodialysis（ HFHD） in patients with leptin and TNF alpha removal effect. Methods： Use prospective controlled study,itself. 120 maintenance low flux hemodialysis patients into high flux hemodialysis treatment for 6 months. Were determined before high flux dialysis treatment（ 0）,3 months,6 months after treatment the patient＇s level of leptin and TNF alpha. Results： High flux dialysis before（ 0 months） in patients with leptin,the TNF alpha level were（ 8. 21 ± 4. 18） ng/ml,（ 16. 91 ± 6. 14） ng/ml. After six months,it was reduced to（ 5. 54 ± 3. 39） ng/ml,（ 14. 36 ± 2. 94） ng/ml,P〈0. 017,P〈0. 017,with statistical significance. Conclusion： Patients with high flux hemodialysis can effectively remove the leptin and TNF alpha,To better improve the micro inflammation state and malnutrition of patients,Improve the patients quality of life.