疏肝益阳胶囊联合舍曲林治疗早泄临床观察

Efficacy of Shugan Yiyang Capsules combined with sertraline on premature ejaculation

目的:观察疏肝益阳胶囊联合盐酸舍曲林治疗早泄(PE)的临床疗效。方法:192例早泄患者随机分为盐酸舍曲林联合疏肝益阳胶囊治疗组和单用盐酸舍曲林对照组,对照组口服盐酸舍曲林片,50 mg/次,每晚1次。治疗组在对照组基础上,予疏肝益阳胶囊,4粒/次,3次/日口服。两组均连续治疗6周。评定治疗前、治疗6周后、停药6周后中国早泄患者性功能评价表(CIPE-5)评分及阴道内射精潜伏期(IELT)。结果:治疗组IELT:治疗前为(1.41±0.53)min,治疗6周后为(6.69±3.56)min;CIPE-5评分:治疗前(9.80±2.06)分,治疗6周后为(21.62±4.76)分。对照组IELT:治疗前为(1.43±0.48)min,治疗6周后为(5.37±2.91)min;CIPE-5评分:治疗前(9.41±1.97)分,治疗6周后为(20.85±4.83)分。两组患者各指标治疗6周后较治疗前均显著改善(P均<0.05)。对照组停药6周后IELT时间[(1.19±1.34)min]与CIPE-5评分[(10.59±2.38)分]与治疗前相比较均无显著差异(P>0.05);治疗组在停药6周后IELT时间[(3.77±1.63)min]、CIPE-5评分[(16.92±3.37)分],与治疗前相比较,差异均有显著性(P均<0.05)。结论:疏肝益阳胶囊联合舍曲林治疗早泄疗效确切,效果持久。

Objective： To observe the clinical effect of Shugan Yiyang Capsules combined with sertraline in the treatment of premature ejaculation （PE）. Methods ： We randomly assigned 192 PE patients to receive sertraline hydrochloride 50 mg qd （ control group, n = 96） or scrtrafine hydrochloride 50 mg qd plus Shugan Yiyang Capsules at the dose of 4 capsules tid （ combination therapy group, n = 96）, both for 6 weeks. We compared the intravaginal ejaculatory latency time （IELT） and Chinese Index of Premature Ejaculation （CIPE） scores between the two groups of patients before and after medication and at 6 weeks after drug withdrawal. Results ： Compared with the baseline, the IELT was significantly increased after 6 weeks of medication in the combination therapy group （[1.41 ±0.53] vs [6.69 ± 3.56] min, P 〈0.05） and the control group （[1.43 ±0.48] vs [5.37 ±2.91] min, P 〈 0.05）, and so was the CIPE score in the former （9.80 ±2.06vs21.62 ±4.76, P 〈0.05） and the latter group （[9.41 ±1.97] vs [20.85± 4.83], P 〈0.05）. In comparison with the pre-medication indexes, the IELT （ [3.77 ±1.63] min） and CIPE score （ 16.92 ± 3.37 ） of the combined therapy group were remarkably improved at 6 weeks after drug withdrawal （ P 〈 0.05 ）, but not those of the eontrol （ [1.19 ±1.34] rain and 10.59 ±2.38, P 〉0.05）. Conclusion： Shugan Yiyang Capsules eombined with sertraline have a definite and lasting effect on premature ejaculation.