脑卒中高危人群视网膜中央动脉血流动力学与亚临床脑梗死的相关性研究

Correlation study of hemodynamics of central retinal artery and subclinical brain infarcts in patients with higher risk of stroke

目的：采用超声多普勒检测视网膜中央动脉（CRA）的血流动力学参数，并与亚临床脑梗死（SBI）做相关性分析，探讨其对SBI的预测作用。方法：149例脑卒中高危人群行MRI颅脑扫描，将其分为62例MRI有梗死灶的SBI组（观察组）和87例MRI无梗死灶的正常组（对照组）。应用彩色超声诊断仪检查CRA的血流频谱，测量CRA收缩期最大峰值血流速度（PSV）、舒张末期血流速度（EDV）、血流阻力指数（RI）。采用SAS统计软件做两样本的t检验。结果：观察组MRI脑梗死灶总数226个，主要分布于额叶及基底神经节，大小3～10mm。观察组CRA的PSV和EDV较对照组显著降低，RI显著增高。结论：脑卒中高危人群中SBI患者存在CRA血流动力学改变，高危人群中CRA血流动力学参数可以作为SBI的筛查指标。

Objective：To study the hemodynamic parameters of central retina artery （CRA） with color Doppler ultrasonography （CDUS） in patients at higher risk of stroke and correlated with subclinical brain infarct （SBI）, in order to investigate the role of CDUS in the forecasting of SBI. Methods： One hundred and forty-nine patients at higher risk of stroke had MRI of brain. They were divided into two groups according to whether SBI was existed on MRI, 62 patients with SBI as study group and 87 cases without SBI as control group. The hemodynamic parameters of CRA including peak systolic veloci- ty （PSV）,end of diastolic velocity （EDV） and resistant index （RI） were studied by CDUS. Two sample t-test was carried out to make correlation analysis with SAS. Results：Of the 226 infarcts in study group,the lesions mostly located at frontal lobe and basal ganglion,the size ranged from 0.3cm to 1.0cm in diameter. The PSV and EDV of CRA values in study group were obviously decreased and RI was markedly increased as compared with that of control group. Conclusion： The hemodynamic changes of CRA could he detected in patients with SBI and the hemodynamic parameters could be used as an index for SBI screening.