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抑癌基因Fibulin-1在肿瘤中的研究进展 被引量：1

Research progress of suppressor genes Fibulin-1 in tumor
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摘要 Fibulin-1是一个分布广泛、功能多样的钙离子结合分泌性糖蛋白,对细胞外基质结构的形成、细胞间信号传导的调节、细胞运动力的抑制有重要作用.近年研究提示,Fibulin-1在肿瘤中扮演抑癌基因角色,本文就Fibulin-1在肿瘤中表达功能及作用机制等研究进展作一综述. Fibulin-1 is a widely distributed,versatile secretory calcium-binding glycoprotein which plays an important role on the formation of the structure of the extracellular matrix,the regulation of intercellular signaling and the inhibition of cell motility.Recent studies suggested a tumor-suppressive role for Fibulin-1.Here,this review focuses on the expression,function and mechanism of Fibulin-1 genes in tumor.
作者 冯亮 薛万江 毛勤生
机构地区 南通大学附属医院普外科
出处 《国际外科学杂志》 2015年第10期705-708,共4页 International Journal of Surgery
基金 国家自然科学基金青年科学基金（No.81000984） 江苏省“六大人才高峰”项目（No.2011WS066）
关键词 Fibulin-1 肿瘤 基因 Fibulin- 1 Neoplasms Genes
分类号 R735.2 [医药卫生—肿瘤]
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参考文献28

  • 1Argraves WS, Oxlund CS, Cangemi C, et al. Low- dose spironolac- tone reduces plasma fibulin- 1 levels in patients with type 2 diabetes and resistant hypertension[ J ]. J Hum Hypertens, 2015, 29 ( 1 ) : 28-32.
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二级参考文献18

  • 1Cheng YY, Jin H, Liu X, et al. Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer. Br J Cancer, 2008,99(12): 2083-2087.
  • 2Pupa SM, Argraves WS, Forti S, et al. Immunological and pathobiological roles of fibulin-l in breast cancer. Oncogene, 2004, 23(12): 2153-2160.
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  • 6Weigell-Weber M, Sarra GM, Kotzot D, et al. Genomewide homozygosity mapping and molecular analysis of a candidate gene located on 22q13 (fibulin-I) in a previously undescribed vitreoretinal dystrophy. Arch Ophthalmol, 2003, 121 (8): 1184-1188.
  • 7Kubota Y, Kuroki R, Nishiwaki K. A fibulin-I homolog interacts with an ADAM protease that controls cell migration in C. elegans. Curr Bioi, 2004, 14(22): 2011-2018.
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国际外科学杂志
2015年 第10期

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