强化铁食物联合铁补充剂治疗儿童缺铁性贫血的效果

Case-control study on iron fortified food combined with supplements- iron in treatment of child iron-deficiency anemia

目的探讨强化铁食物联合铁补充剂治疗儿童缺铁性贫血的效果。方法选择收治的899例6个月~6岁贫血儿童,随机平均分为对照组和观察组。对照组患儿早餐后,口服小剂量硫酸亚铁（5 mg/kg）和维生素C（50~100 mg）。观察组患儿采用富含铁食物和铁剂结合进行。每组疗程均为两个月。结果与治疗前相比较,治疗后观察组和对照组患儿的Hb、血清铁蛋白（SF）和血清运转蛋白饱和度（TS）均有所提高,其中Hb和SF治疗前后差异有统计学意义（P〈0.05）,且观察组各指标升高的数值均高于对照组。此外,两组患儿分别有410和403例治疗效果为治愈,均没有无效例数。结论强化铁食物结合铁补充剂治疗缺铁性贫血后,患儿的Hb、SF和TS均有所提高,各指标数值均高于单纯铁补充剂治疗的对照组。

Objective To explore the effects of iron-enriched food and iron-supplements on children with iron deficiencyanemia. Methods A total of 899 children with iron deficiency anemia aged from 6 months to 6 years old were randomlydivided into control group and observation group. Children in control group were administrated with oral low-dose（5 mg/kg）ferrous sulfate after breakfast, children in observation group were administrated with iron-enriched foods and oral iron. Thecourses of the study lasted for two months. Results After treatment, the hemoglobin（Hb）, serum feritin（SF）, and serum totalcholesterol（TS）were increased in the two groups compared to those before the treatment. The differences in Hb and serum SF（P〈0.05）were significant, and the indexes in observation group increased more than those in control group did. In addition,410 cases in observation group and 403 in control group were cured. No invalid case was found. Conclusion The treatmentwith iron-enriched foods and oral iron increased the Hb, serum SF and TS in children with iron deficiency anemia, and theincreases of these parameters were higher those that of cases who took oral ferrous sulfate only.