硫普罗宁注射液治疗乙型病毒性肝炎合并肺结核的临床疗效

Effect of tiopronin injection in treating hepatitis B and tuberculosis

目的探讨硫普罗宁注射液治疗乙型病毒性肝炎(乙肝)合并肺结核的临床疗效。方法选取2013年1月—2014年10月攀枝花市第四人民医院收治的乙肝合并肺结核患者138例,随机分为对照组与观察组,各69例。两组患者均采用HRZE方案进行抗结核治疗,对照组患者在抗结核期间予以齐墩果酸片进行保肝治疗,观察组患者在抗结核期间予以硫普罗宁注射液进行保肝治疗。观察两组患者治疗前后肝功能指标〔丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBi L)〕、抗结核治疗效果(空洞闭合、病灶吸收、痰菌转阴)、临床症状(发热、咳嗽、盗汗)持续时间及不良反应发生情况。结果治疗前两组患者ALT、AST、TBi L水平比较,差异无统计学意义(P>0.05),治疗后观察组患者ALT、AST、TBi L水平低于对照组,差异有统计学意义(P<0.05);两组患者空洞闭合率比较,差异无统计学意义(P>0.05),观察组患者病灶吸收率及痰菌转阴率高于对照组,差异有统计学意义(P<0.05);观察组患者发热、咳嗽、盗汗持续时间短于对照组,差异有统计学意义(P<0.05);观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论硫普罗宁注射液治疗乙肝合并肺结核的临床疗效显著,可提高患者肝功能及抗结核治疗效果,改善患者临床症状,且不良反应少。

Objective To explore the effect tiopronin injection in treating hepatitis B and tuberculosis. Methods A total of 138 patients with hepatitis B and tuberculosis were selected in Fourth People＇s Hospital of Panzhihua from January 2013 to October 2014,they were randomly divided into control group and observation group,69 cases in each group. Two groups adopt HRZE scheme for anti- tuberculosis treatment,control group during anti- tuberculosis treatment were given oleanolic acid tablets for protecting liver treatment,observation group during anti- tuberculosis treatment were given tiopronin injection for protecting liver treatment. Before and after treatment liver function index 〔alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,total bilirubin（ TBi L） 〕,anti- tuberculosis treatment effect（ pore closure,lesions absorption,sputum became negative）,clinical symptoms（ fever,cough,night sweat） duration and incidence of adverse reactions between the two groups were compared. Results Before treatment,ALT,AST,TBi L showed no significant differences between the two groups（ P〉0. 05）,after treatment,ALT,AST,TBi L of observation group were lower than those of control group（ P〈0. 05）; pore closure rate showed no significant differences between the two groups（ P〈0. 05）,lesions absorption rate and sputum became negative rate of observation group were higher than those of control group（ P〉0. 05）; fever,cough,night sweat duration of observation group were shorter than those of control group（ P〈0. 05）; incidence of adverse reactions of observation group was lower than that of control group（ P〈0. 05）. Conclusion Tiopronin injection has notable curative effect in the treatment of hepatitis B and tuberculosis,can relieve the patients＇ clinical symptoms,has less adverse reaction.