七氟醚不同诱导方式对手术患者血流动力学的影响

Impact of different sevoflurane inductions on hemodynamics in patients with operation

目的探讨七氟醚不同诱导方式对手术患者血流动力学的影响。方法选取成都市第三人民医院2012年10月—2014年12月收治的于全麻下行择期手术的患者200例,随机分为对照组和观察组,每组100例。观察组采用逐渐增加吸入浓度诱导方法,对照组采用高浓度快速吸入诱导方法,比较两组麻醉诱导时间、苏醒时间、拔管时间和清醒时间以及各时间点〔麻醉前(T1)、麻醉给药或吸入诱导后2min(T2)、麻醉给药或吸入诱导后5min(T3)、麻醉给药或吸入诱导后8min(T4)、麻醉给药或吸入诱导后10min(T5)〕的心率和血压。结果两组麻醉诱导时间、苏醒时间、拔管时间和清醒时间比较,差异无统计学意义(P>0.05)。观察组患者心率在T2、T5时间点与对照组比较,差异有统计学意义(P<0.05);对照组心率T3、T5时间点与T1比较,差异有统计学意义(P<0.05),观察组心率T2、T3时间点与T1比较,差异有统计学意义(P<0.05)。观察组患者血压在T3时间点与对照组比较,差异有统计学意义(P<0.05);对照组血压在T3时间点与T1比较,差异有统计学意义(P<0.05)。结论七氟醚逐渐增加吸入浓度诱导方法麻醉效果良好,安全有效,对患者的血流动力学影响较小。

Objective To investigate impact of different sevoflurane inductions on hemodynamics in patients with operation. Methods From October 2014 to December 2012 in the Third People＇s Hospital of Chengdu,a total of 200 patients undergoing general anesthesia were selected and randomly divided into control group and observation group,100 cases in each group. The observation group were given gradually increased inhale concentration induction,the control group were given high-concentration rapid inhalation induction,anesthesia induction time,awakening time,removal time,conscious time,heart rate and blood pressure of different time points 〔pre- anesthesia（ T1）,2 min after induction dosing or inhaled（ T2）,5min（ T3）,8min（ T4）,10min（ T5） 〕between the two groups were compared. Results Anesthesia induction time,awakening time,removal time,conscious time between the two groups showed no significant differences（ P〉0. 05）. The heart rate of the observation group at T2 and T5time points compared with control group,the difference was statistically significant（ P〈0. 05）.The heart rate of the control group at T2 and T5time points compared with T1,the difference was statistically significant（ P〈0. 05）; the heart rate of the observation group at T2 and T5time points compared with T1,the differences were statistically significant（ P〈0. 05）. Blood pressure of the observation group at T3 time point compared with control group,the difference was statistically significant（ P〈0. 05）. Blood pressure of the control group at T3 time point compared with T1,the difference was statistically significant（ P〈0. 05）. Conclusion Anesthesia effect of sevoflurane gradually increased concentrations is good,safe and effective,the impact on the patient＇s hemodynamics is less.