甲强龙与氢化可的松治疗慢性阻塞性肺疾病急性加重期的疗效对比

Effect comparison of methylprednisolone and hydrocortisone in treating acute exacerbation of chronic obstructive pulmonary disease

目的比较甲强龙与氢化可的松治疗慢性阻塞性肺病(COPD)急性加重期的临床疗效。方法选择2013年1—6月入住湖北省新华医院的COPD急性加重期患者62例,随机分为甲强龙组30例和氢化可的松组32例。甲强龙组给予甲强龙治疗,氢化可的松组给予氢化可的松治疗,比较两组的肺功能〔第1秒用力呼气容量(FEV1)、肺活量(FVC)〕和动脉血气分析指标。结果治疗后第3天两组FEV1、FVC、Pa O2、Pa CO2比较,差异无统计学意义(P>0.05),第10天两组FEV1、FVC、Pa O2、Pa CO2比较,差异有统计学意义(P<0.05)。结论甲强龙与氢化可的松治疗COPD急性加重期的疗效显著,甲强龙改善肺功能的效果优于氢化可的松。

Objective To compare the clinical effect of methylprednisolone and hydrocortisone in the treatment of a-cute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods A total of 62 patients with acute exacerbation of COPD hospitalized from January 2013 to June 2013 in Hubei Xinhua Hospital were selected,and they were randomly divided into 30 cases of methylprednisolone group and 32 cases of hydrocortisone group. Methylprednisolone group was given methylpred-nisolone therapy,hydrocortisone group was given hydrocortisone therapy,lung function（FEV1、FVC）and arterial blood gas a-nalysis between the two groups were compared. Results 3 days after treatment FEV1 ,FVC,PaO2 ,PaCO2 between the two groups were compared,the differences were not statistically significant（ P 〉 0. 05）,10 days after treatment FEV1 ,FVC, PaO2 ,PaCO2 between the two groups were compared,the differences were statistically significant（P 〈 0. 05）. Conclusion Methylprednisolone and hydrocortisone both have remarkable effect in treatment of COPD patients with acute exacerbation,the lung function improving of methylprednisolon is better than hydrocortisone.