广东省阳江地区3852例妇女子宫颈人乳头瘤病毒感染及其亚型分布

Analysis of 3852 women with cervical infection of human papilloma virus and its genotypes distribution in Yangjiang

目的：了解广东省阳江市城市妇女人乳头瘤病毒（HPV）感染现状和基因型分布.方法：收集2013年4月～2013年10月广东省阳江市3852名城市妇女宫颈脱落细胞标本,采用基质辅助激光解吸电离飞行时间质谱技术对16种HPV基因型进行检测.结果：3852名调查对象年龄（40.05±7.61）岁,HPV总感染率为4.3％,混合感染占11.5％.＜35岁、35～ 44岁、45～ 54岁和≥55岁年龄组检出率分别为5.7％、3.8％、3.6％和4.4％,各年龄分布检出差异无统计学意义.HPV感染率的年龄曲线呈＂＂字型双峰.结论：阳江地区城市女性HPV感染率相对较低,主要为单一型别感染,感染优势型别依次是HPV52、HPV16、HPV18和HPV58.

Objective： To analyze the situation of human papilloma virus （HPV） infection in urban women of YangJiang and its genotype distribution. Method： From April 2013 to October 2013, cervical exfoliated cell of 3852 urban women were collected and 16 different kinds of HPV genotypes were detected by SELDI TOF MS technique. Result： the mean age of these women was 40.05±7.61years. HPV infection was found in165 women, and the infection rate was 4.3%, the rate of multiple HPV infection was 11.5%/00. The HPV infection rate in women under of 35 years,35N 44 years women,45-- 54 years women,and older than 55 years was 5.7%, 3.8~ , 3.6% , and 4.4o//00, respectively, there were no statists difference among different age groups. The distribution characteristics of women with HPV infection was twin peaks liked＂V＂. Conclusion：The HPV infection was low in YangJiang region, which mainly caused by single HPV genotypes. The most prevalent genotype in YangJiang was HPV52, followed by HPV16, HPV18 and HPV58.