摘要
目的探讨染色质组装因子(CAF-1)p60在非小细胞肺癌中的预后价值,分析其与临床病理特征的相关性。方法连续性选取179例非小细胞肺癌肿瘤组织,采用免疫组化法检测肿瘤组织中CAF-1 p60的表达,分析其与临床病理特征的相关性及预后意义。结果 CAF-1 p60在肺癌组织中为核表达。CAF-1 p60高表达率为47.5%(85/179),低表达率为52.5%(94/179)。CAF-1 p60表达与TNM分期(P<0.001)、肿瘤分化程度(P=0.018)、远处转移(P=0.011)密切相关。KaplanMeier生存曲线提示,CAF-1 p60高表达患者的生存率明显低于低表达者(P<0.001)。Cox多变量生存分析提示,CAF-1 p60高表达是重要的独立预后因素(HR=2.747,P=0.001)。结论在非小细胞肺癌中,CAF-1 p60高表达提示预后不良,并且与肿瘤分期、分级及远处转移相关。CAF-1 p60可以作为非小细胞肺癌的独立预后因子。
Objective To explore the prognostic value of CAF-1 p60 in non-small cell lung cancer and evaluate the relationship between CAF-1 p60 expression and clinicopathological data. Methods The expressions of CAF-1 p60 were detected by immunohistochemistry in specimens from 179 patients with primary non-small cell lung cancer. Its correlations to clinicopathological characteristics and patients＇ outcome were also investigated. Results CAF-1 p60 was observed in the nucleus of non-small cell lung cancer cells,with high expression rate 47. 5%（ 85 /179） and low expression rate 52. 5%（ 94 /179）. CAF-1 p60 was associated with tumor-node-metastasis（ TNM） stage,tumor differentiation and metastasis during followup. Kaplan-Meier curve demonstrated that the survival rate of CAF-1 p60 high expression group was obviously lower than the low expression group（ P 0. 001）. Cox multivariate analysis demonstrated CAF-1 p60 was an independent prognostic factor（ HR = 2. 747,P = 0. 001）. Conclusions High expression of CAF-1p60 predict poor outcome,and associated with TNM stage,tumor differentiation and metastasis. CAF-1 p60 is an independent prognostic factor in non-small cell lung cancer.
出处
《中国肿瘤临床与康复》
2015年第11期1292-1295,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
