血清胸苷激酶-1水平在鼻咽癌患者治疗过程中的动态变化及与病理学特征的关系

The change of serum TK1 level in the treatment process of the early cure nasopharyngeal carcinoma patients and its relationship to pathological features

目的考察血清胸苷激酶-1（TK1）在鼻咽癌患者治疗过程的变化及与病理学特征的关系。方法收集该院2010-2013年在放疗科收治的鼻咽癌患者35例,选择同期鼻咽部炎症患者20例为对照。比较治疗前后血清TK1水平。结果治疗前后,对照组TK1无显著变化（P〉0.05）;与对照组比,治疗前后鼻咽癌组的TK1均较高（P〈0.05）;与治疗前比,治疗后鼻咽癌组的TK1显著降低（P〈0.05）。治疗前后,鼻咽癌Ⅰ-Ⅱ期的TK1均低于Ⅲ-Ⅳ期（P〈0.05）,无淋巴结转移均低于淋巴结转移（P〈0.05）,颈神经未侵犯低于颈神经侵犯（P〈0.05）,颅底未受侵低于颅底受侵（P〈0.05）,未分化癌高于高中分化鳞癌和低分化鳞癌（P〈0.05）。TNMⅣ期、淋巴结转移、颈神经侵犯TK1表达较高（P〈0.05）。结论 TK1可反映鼻咽癌患者的肿瘤负荷和增殖活性,对鼻咽癌诊断、监测病情和预后有应用前景。

Objective To learn the change of serum thymidine Kinase 1（TK1）level in the treatment process of the early cure nasopharyngeal carcinoma patients and its relationship to pathological features.Methods From January 2010 to December 2013,35 cases of nasopharyngeal carcinoma patients were collected into our study,20 cases of nasopharyngeal inflammation patients were chosen as the control.Serum TK1 level in the 2groups was compared before and after treatment.Results TK1 in control group had no significant differences before and after treatment（P〈0.05）.Compared with the control group,serum TK1 in nasopharyngeal carcinoma group were higher before and after radiotherapy（P〈0.05）;after radiotherapy,serums TK1 in nasopharyngeal carcinoma group were lower（P〈0.05）.Before and after radiotherapy,serum TK1 Ⅰ and Ⅱ stage were lower than in Ⅲ and Ⅳ stager（P〈0.05）,lymph node metastasis group were higher than no lymph node metastasisr（P〈0.05）,TK1 had higher expression in TNMⅣthan TNM Ⅱ（P〈0.05）,compared with lymph node metastasis and cervical nerve violated groups,TK1 expression was higher in none lymph node metastasis and none cervical nerve violated groups（P〈0.05）.Conclusion TK1 can reflect the tumor load and proliferative activity of nasopharyngeal carcinoma,which could be as a factor in nasopharyngeal carcinoma diagnosis,monitoring and prognosis.