基因修饰猪模型应用于人类健康的相关研究进展

Progress of Genetically-modified Pigs in the Human Health Related Research

猪在解剖结构及生理功能上比啮齿类动物更接近于人类,与非人灵长类动物相比,具有来源方便,伦理问题少等优点。因此,猪模型在人类健康相关研究上具有非常广泛的应用前景。本文主要介绍猪在模拟人类疾病模型上以及在作为异种器官移植供体研究上近年来的研究进展;同时也介绍了我们在国家重大科学研究计划"生殖与发育相关猪模型的建立"项目中取得的一些成果。

Swine are more analogous to humans than rodents in anatomy and physiology. Comparing with non-human primates, pigs are more easily available and have less ethical concern. Therefore pigs have more extensive applications in the human health related research field. In this review, we mainly summarize the progress of generation of genetically-modified pigs in modeling various human diseases and xenotransplantation. We also describe some achievements on a project about generation of genetically-modified pigs for reproduction and development funded by Ministry of Science and Technology of China.