美托洛尔联合呋塞米治疗心功能Ⅲ～Ⅳ级心力衰竭患者临床疗效观察

Effect of metoprolol combined with furosemide on heart faiure patients with cardiac function stage Ⅲ-Ⅳ

目的：探讨美托洛尔联合呋塞米治疗心力衰竭患者的临床效果。方法回顾性分析武陟县第二人民医院2012年1月至2014年1月收治的86例心功能Ⅲ～Ⅳ级心力衰竭患者的临床资料，根据治疗方法的不同将患者随机分成对照组和治疗组，每组43例，对照组给予单纯呋塞米治疗，治疗组给予美托洛尔联合呋塞米治疗。比较两组患者的临床治疗效果和不良反应的发生情况。结果对照组治疗有效率为81.40％，治疗组为95.35％，治疗组有效率明显高于对照组（P＜0.05）；对照组不良反应发生率为20.93％，治疗组为4.65％，治疗组不良反应发生率明显低于对照组（ P＜0.05）。结论对于心功能Ⅲ～Ⅳ级的心力衰竭患者，临床上给予美托洛尔联合呋塞米治疗的效果较好，能够明显提高临床治疗有效率，同时不良反应少，值得临床广泛推广使用。

Objective To investigate the effect of metoprolol combined with furosemide on pa-tients with heart failure.Methods The clinical data of 86 heart faiure patients with cardiac function stage Ⅲ-Ⅳfrom January 2012 to January 2014 were retrospectively analyzed.Depending on the method of treatment, the patients were randomly divided into the control group and the treatment group, with 43 cases in each group.The patients in the control group were treated with metoprolol alone, and the pa-tients in treatment group were treated with metoprolol combined with furosemide.The clinical effects and adverse reactions were compared.Results The effective rate in control group was 81.40%, and the ef-fective rate in treatment group was 95.35%, there was significant difference （ P〈0.05 ） .The incidence of adverse reactions in control group was 20.93%, and that in treatment group was 4.65%, there was significant difference （ P〈0.05 ） .Conclusions For heart failure patients with cardiac function stageⅢ-Ⅳ, metoprolol combined with furosemide therapy has better effect, can significantly improve the clinical efficiency, has fewer adverse reactions, it is worthy of widespread in clinics.