摘要
1型糖尿病是一种具有遗传倾向的慢性病。该类型糖尿病是由胰岛β细胞受到自身免疫的攻击产生不可逆破坏所致,属于胰岛素依赖性糖尿病。传统的治疗方法有胰岛素注射治疗和胰腺胰岛移植等。近几年随着干细胞研究的发展,诱导干细胞分化形成可分泌胰岛素的类β细胞的技术日渐完善,这为治疗1型糖尿病提供了新的技术支持。文章阐述了1型糖尿病的发病机制及干细胞应用于糖尿病治疗的研究进展。
Type 1diabetes mellitus（T1DM）is a chronic disease,which has an inherited tendency.T1 DM is an insulin-dependent diabetes.Insulin-secretingβ-cells of patients with T1 DM are selectively and irreversibly destroyed by autoimmune,so that these cells lose their function to secrete insulin.Traditional methods to cure T1 DM include insulin injections and pancreas islet transplantation.Recently with the development of stem cells technique,we can get insulin-secretingβ-cells from different types of stem cells.These new techniques have provided a new chance to heal T1 DM.The review summarizes thepathophysiology of T1 DM and we also show some new advances in stem-cell-based approaches that could be applied to treat diabetes in the future.
出处
《中国畜牧兽医》
CAS
北大核心
2015年第11期3099-3104,共6页
China Animal Husbandry & Veterinary Medicine
基金
中国农业科学院科技创新工程项目(cxgc-ias-01)
国家家养动物种质资源平台项目(2015年)
