用全身PET/CT寻找转移瘤患者的原发灶

Diagnostic value of ^(18)F-FDG PET/CT imaging in metastatic carcinoma of unknown primary tumor

目的:对不明原因转移瘤患者,探讨利用正电子发射计算机断层显像(positron emission tomography/computed tomography,PET/CT)寻找肿瘤原发灶的临床价值。方法:回顾性收集经病理学证实或影像学检查诊断为转移瘤的137例住院患者的临床及PET/CT成像资料,计算全身PET/CT显像对不明原因转移瘤患者肿瘤原发灶的检出率,分析不同部位转移瘤原发灶检出率间的差异。结果:确诊1例淋巴瘤患者被排除,18FFDG PET/CT正确检出原发病灶89例,检出率为65.4%(89/136)。18F-FDG PET/CT对于淋巴结转移、骨转移、肝转移及脑转移瘤肿瘤原发灶检出率分别为63.2%(36/57)、60.0%(18/30)、86.7%(13/15)和57.1%(8/14)。结论:全身PET/CT显像在不明原因转移瘤寻找肿瘤原发灶方面具有重要临床应用价值。

Objective： To explore the value of whole body PET/CT scan with（ 18） F-fluorodeoxy glucose（ FDG）in the diagnosis of metastatic carcinoma of unknown primary origin（ CUP）. Methods： A retrospective study was performed in patients diagnosed of metastatic carcinoma with CUP. All patients were confirmed by pathology or diagnostic imaging examinations. The recruited patients were received whole body ^18F-FDG PET-CT scan. Histopathological findings were used to determine the diagnostic value of ^18F-FDG PET-CT. Results： Total of 136 patients were included in the study. The primary tumor site was accurately identified by^18F-FDG PET / CT in 89 patients（ 89 /136,65. 4%）. The detection rate of the primary tumor site for metastatic lymph node carcinoma,bone metastasis,liver metastasis and brain metastasis were 63. 2%（ 36 /57）,60%（ 18 /30）,86. 7%（ 13 /15） and 57. 1%（ 8 /14） respectively. Conclusion： Whole body ^18F-FDG PET / CT has important clinical value in detecting primary site of CUP.