月经初潮年龄对中国女性乳腺癌临床病理特征及分子表型的影响

Influence of age at menarche on clinical pathological features and molecular phenotype in Chinese female breast cancer

目的:探索中国女性月经初潮年龄对乳腺癌临床病理特征及分子表型的影响。方法:收集本院收治的女性乳腺癌临床资料共210例,按月经初潮年龄分为≤13岁组和>13岁组,采用卡方检验分别比较各组间临床病理特征及分子表型的差异。结果:月经初潮年龄越早(≤13岁),腋窝淋巴结转移几率越高,同时肿瘤分期越晚(P<0.05);初潮年龄越早,非Luminal型出现的比例越高(P<0.05)。结论:月经初潮越早,乳腺癌的恶性程度越高并且多呈现出非Luminal型的分子表型。

Objective：To investigate the influence of age at menarche on tumor clinical characteristics and molec- ular subtypes in Chinese females with breast cancer. Methods：The clinical findings of 210 Chinese females withbreast cancer were divided into 2 groups： ~〈 13 years old and 〉 13 years old, then analyzed as age at menarche retro- spectively. Results：The age of menarche ~〈 13 years old was a higher risk factor of axillary lymph nodes metastasis, later TNM staging and non - Luminal subtype than that of 〉 13 years old（ P 〈 0.05 ）. Conclusion： Earlier age at menarche might be related to higher grade malignancy,TNM staging and appearance of non - Luminal subtype in Chi- nese females with breast cancer.