摘要
目的:观察扶正抑癌方对非小细胞肺癌(NSCLC)化疗患者的近期疗效及其对免疫功能的影响;对中晚期非小细胞肺癌患者生存质量及机体免疫功能的影响。方法:中药治疗:扶正抑癌方辨证加减内服,每天1剂,30天为1个疗程。化疗:长春瑞滨25mg/m2,第1、8天,顺铂20~30mg/m2,第1~3天,外周静脉滴注,21天为1个疗程。4个疗程后评价疗效。观察近期疗效、临床证候变化、治疗前后免疫功能变化及生活质量变化。结果:治疗后治疗组瘤体稳定率89.28%,显著高于对照组的71.42%(P〈0.05)。治疗组中医证候改善的总有效率(71.42%)与对照组(39.28%),差异有统计学意义(P〈0.01)。治疗组和对照组卡氏评分总有效率分别为67.85%、42.85%,差异有统计学意义(P〈0.01)。治疗组治疗后免疫指标CD3+、CD4+、CD4+/CD8+比值、自然杀伤细胞(NK细胞)活性、治疗前后自身对照差异有统计学意义(P〈0.05)。两组治疗后比较NK、CD4+/CD8+比值升高差异有统计学意义(P〈0.05)。结论:采用扶正抑癌方联合化疗治疗中晚期非小细胞肺癌,可提高机体免疫功能,提高患者生活质量,延长生存期,是一种疗效肯定、安全性高、并发症少的综合治疗方法。
Objective:To obverse the impact on curative effect and immune function of NSCLC patients treated with Fuzheng Yi'ai Decoction in the medium or late stage NSCLC patients. Methods:Fuzheng Yi'ai Decoction were given and modified according to different clinical symptoms, one dose a day for 30 days as one course of treatment. Chemotherapy : Vinorelbine ( 25 mg/m2 in the 1 st and 8 th day) and Cisplatin ( 20 - 30mg/m2 from the 1 st to 3 th day ) were given intravenously,21 days as one course of treatment. After 4 courses of treatment ,curative effect, clinical syn- drome, and the changes of immune function and quality of life, before and after therapy,were observed. Results: After therapy in the treatment group tumors stable rate was 89.28% obviously higher than that the control group 71.42% ( P 〈 0.05 ). The total effective rate of syndrome improvement was 71.42% in treatment and 39.28% in control group ( P 〈 0.01 ). The total effective rate of KPS(Karnofsky performance status) was 67.85 % in treatment group and 42.85 % in control group( P 〈 0.01 ). The immune indexes of CD3 + , CD4 +, CD4 +/CD8 + and NK cells activity, there was a statistical difference ( P 〈 0.05 ) before and after therapy. Conclusion: The medium or late stage NSCLC patients trea- ted by Fuzheng Yi'ai Decoction with chemotherapy ,which can improve the patents" immune function and life quality, and prolong patients" survival period.
出处
《现代肿瘤医学》
CAS
2015年第24期3606-3609,共4页
Journal of Modern Oncology
关键词
非小细胞肺癌
中西医结合疗法
免疫学
NSCLC, traditional Chinese medicine and Western medicine therapy,immunology