慢性阻塞性肺疾病患者急性加重期降钙素原、超敏C反应蛋白及D-二聚体水平变化的临床意义

The clinical significance of level changes in procalcitonin,hypersensitive c-reactive protein and D-dimer in the acute exacerbation of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病(COPD)患者急性加重期(AECOPD)降钙素原(PCT)、超敏C反应蛋白(hs-CRP)及D-二聚体(D-Dimer)水平变化的临床意义。方法 2013年12月至2014年12月因COPD加重在我院呼吸内科住院的30例患者为观察组;同期在我院呼吸内科门诊随访的30例COPD稳定期患者为对照组。分别检测两组患者PCT、hs-CRP及DDimer水平。结果观察组患者入院时的PCT、hs-CRP、D-Dimer水平均高于对照组,差异有统计学意义(t分别为10.91、12.47和19.26,均P<0.05);观察组患者出院时的PCT、hs-CRP、D-Dimer水平均低于入院时,差异有统计学意义(t分别为9.11、11.63和16.28,均P<0.05),与对照组比较,差异无统计学意义(P>0.05)。结论 AECOPD患者PCT、hs-CRP、D-Dimer水平在治疗后明显降低,检测三者水平可以预测COPD的发展与严重程度,为临床预防与治疗提供帮助。

Objective To investigate the significance of level changes in procalcitonin（ PCT）,hypersensitive c-reactive protein（ Hs-CRP） and D-dimer in the acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods Thirty patients with AECOPD from December 2013 to December 2014 admitted at the department of respiratory medicine in our hospital were selected as observation group. At the same time,another 30 outpatients with stable COPD patients were used as control group. The levels of PCT,Hs-CRP and D-Dimer were detected. Results The levels of PCT,hs-CRP and D-dimer on admission in the observation group were significantly higher than that in the control group（ t values were 10. 91,12. 4 and 19. 26,respectively,all P〈0. 05）. The levels of these indexes were lower when out of the hospital than that on admission（ t values were 9. 11、11. 63 and 16. 28,respectively,all P〈0. 05）but were not different from that of the control group（ P〉0. 05）. Conclusion The levels of PCT,hs-CRP and D-dimer in AECOPD patients are significantly decreased. Therefore,detection of these indexes can predict the development and severity of the disease and thus provide the help for the clinical prevention and treatment.