馥感啉口服液治疗35例小儿手足口病的临床观察

Clinical observation of oral Fuganlin in the treatment of 35 cases of children with hand,foot and mouth disease

目的观察馥感啉口服液治疗小儿手足口病的临床效果。方法随机选取我院门诊及病房2013年1月-2014年1月诊治的手足口病患儿70例,依据随机数字表法将这些患儿分为治疗组（n=35）和对照组（n=35）两组。治疗组予以馥感啉口服液治疗,对照组给予利巴韦林颗粒口服。然后对两组患儿的退热时间、口腔溃疡愈合时间、手足等部位皮疹消退时间及治疗时间、临床疗效进行统计分析。结果治疗组患儿的退热时间、口腔溃疡愈合时间、手足等部位皮疹消退时间及治疗时间均显著短于对照组（P〈0.05）,治疗的总有效率94.2%（33/35）显著高于对照组82.8%（29/35）,差异有统计学意义（P〈0.05）;治疗组有1例出现皮疹,停药后消退。治疗后两组尿便常规、肝肾功能及心电图复查均无异常。结论馥感啉口服液治疗小儿手足口病的临床效果显著,值得在临床推广。

Objective To observe the clinical effect of oral Fuganlin in the treatment of 35 cases of children with hand,foot and mouth disease.Methods 70 cases of children with hand,foot and mouth disease who received diagnosis and treatment in outpatient and ward from January 2013 to January 2014 were selected,these patients were divided into treatment group（n=35） and control group（n=35） two groups according to a random number table.The treatment group were given Fuganlin oral treatment,while the control group were given oral ribavirin particles.Then the cooling time,oral ulcer healing time,hand,foot and other parts of the rash subsided time and time,the clinical efficacy of two groups were statistically analyzed.Results The fever group time,oral ulcer healing time,hand,foot and other parts of the rash subsided time and treatment time of the treatment group of children were significantly shorter（P〈0.05）;The total effective rate was 94.2%（33/35） in the treatment group was significantly higher than the control group 82.8%（29/35）,the difference was significant between two groups（P〈0.05）.The treatment group had 1 case of rash subsided after discontinuation.After treatment,urine routine,liver and kidney function and ECG were normal review.Conclusion The clinical effect of oral Fuganlin in the treatment of children with foot and mouth disease is significant,so is worthy of promotion in the clinical.