脑胶质瘤中 CDK4 和 β-Catenin 表达及临床意义的研究

The research on CDK4 and β-Catenin expression and clinic significance in glioma

目的 研究脑胶质瘤中CDK4和β-Catenin的表达情况及相关性. 方法 采用免疫组织化学法检测45例脑胶质瘤组织和8例癌旁正常组织中CDK4和β-Catenin的表达,并将其按WHO 2000年神经系统肿瘤病理学分级标准进行分类分级,进行统计学分析. 结果 45例脑胶质瘤组织中CDK4和β-Catenin 阳性表达率分别为73.3%和77.8%,与癌旁正常组织之间的差异具有统计学意义（ P 〈0.05）.CDK4和β-Catenin的表达均与WHO分级和组织学分型相关（P〈0.05）,与患者性别、年龄之间差异无统计学意义（P〉0.05）. CDK4和β-Catenin的表达呈正相关（r=0.52,P〈0.01）,二者表达均阳性患者恶性程度高. 结论 脑胶质瘤中CDK4和β-Catenin的表达增高可能与胶质瘤的恶性变和恶性胶质瘤的发生有关,二者相结合有望成为胶质瘤恶性评估的重要指标.

Objective To study the expression of CDK4 andβ-Catenin and their relevance in glioma. Methods We used immunohistochemistry to detect the expression of CDK4 andβ-Catenin in forty-five glio-ma tissues and eight normal tissues.According to the classification standard of WHO in 2000 classify and grade the tissues.Results There were significant differences of CDK4 andβ-Catenin expressions between normal tis-sues and glioma tissues（P〈0.01）.The expression of CDK4 and β-Catenin had positive correlation with the pathological grades of glioma and histological type and increased（P 〈0.05）.Furthermore,the expression of CDK4 was positively correlated with the expression ofβ-Catenin in glioma（r=0.52,P〈0.01）.Conclusion The increased expression of CDK4 andβ-Catenin may have correlation with malignant change of glioma and oc-curance of glioblastoma,and their combination is expected to become an important indicator in assessing malignant glioma.