初诊2型糖尿病患者周围神经病变相关危险因素分析

Related risk factors for peripheral neuropathy in patients newly diagnosed as type 2 diabetes mellitus

目的探讨初诊2型糖尿病(T2DM)患者并发糖尿病周围神经病变(DPN)的危险因素。方法 170例初诊T2DM患者,根据有无自觉症状及神经传导速度测定有无异常分为无DPN组60例、DPN组110例。将体重指数(BMI)、血压、入院时随机血糖(RBG)、空腹C肽(FCP)、糖负荷后2小时C肽(2h CP)、糖化血红蛋白(Hb A1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、晨尿微量白蛋白/肌酐(UACR)等指标进行单因素分析,对有统计学意义的因素进行多因素logistic非条件回归分析。结果 170例初诊T2DM患者DPN的患病率为64.7%。DPN组年龄、RBG、UACR、Hb A1c高于无DPN组(P<0.05)。多因素logistic非条件回归分析显示,年龄、UACR、Hb A1c为初诊T2DM患者发生并发DPN的危险因素(P<0.05)。结论初诊T2DM患者易并发DPN,年龄、Hb A1c、UACR为初诊T2DM患者发生DPN的危险因素。

Objective To investigate the risk factors for diabetic peripheral neuropathy（ DPN） in patients newly diagnosed as type2 diabetes mellitus（ T2DM）. Methods According to the subjective symptoms and the abnormality of nerve conduction velocity（ NCV）,170 patients newly diagnosed as T2 DM were divided into non-DPN group（ n = 60） and DPN group（ n = 110）. Body mass index（ BMI）,blood pressure,random blood glucose（ RBG） when admission,fasting C-peptide（ FCP）,postprandial 2-hour C-peptide（ 2h CP）,glycosylated hemoglobin（ Hb A1c）,total cholesterol（ TC）,triglyceride（ TG）,low density lipoprotein cholesterol（ LDL-C）,high density lipoprotein cholesterol（ HDL-C）,uric acid（ UA）,the ratio of urinary albumin and creatinine（ UACR） were enrolled in univariant analysis. And the factors with statistical significance were enrolled in multivariate unconditional logistic regression analysis. Results The morbidity of DPN in 170 patients newly diagnosed as T2 DM was 64. 7%. Age,RBG,UACR,Hb A1 c of DPN group were higher than those of non-DNP group（ P〈0. 05）. Multivariate unconditional logistic regression analysis showed that age,UACR and Hb A1 c were the risk factors for DPN in patients newly diagnosed as T2DM（ P〈0. 05）. Conclusion Patients newly diagnosed as T2 DM are liable to complicated with DPN. Age,Hb A1 c and UACR are the risk factors for the onset of DPN in patients newly diagnosed as T2 DM.