超声造影和VTQ技术在甲状腺实性结节诊断中的价值研究

Diagnosis value of contrast-enhanced ultrasound combined with VTQ technology in the thyroid solid nodules

目的:评估超声造影和声触诊组织定量(VTQ)技术在甲状腺实性结节鉴别诊断中的价值。方法:对62例甲状腺实性结节性疾病患者,共96个结节(所有结节性质均经手术病理证实)行超声造影及VTQ检查,分析造影增强特点、时间-强度曲线参数、VTQ参数对甲状腺实性结节的诊断价值。结果:结节性甲状腺肿50个,甲状腺腺瘤15个,甲状腺乳头状癌31个,经卡方检验分析三者在增强程度、增强形态、周边增强方面有显著统计学差异(P<0.01);在结节良、恶性鉴别方面,时间-强度曲线参数中RS-Ratio、IMAX-Ratio曲线下面积相对较大(P<0.01),VTQ参数中SWV、SWV-Ratio曲线下面积大于RS-Ratio、IMAX-Ratio。结论:超声造影增强模式对于鉴别结节的病理类型有重要的研究价值;VTQ技术在鉴别结节良、恶性方面研究价值要大于造影时间-曲线分析。

Objective： To assessment the diagnosis value of thyroid nodules by the contrast-enhanced ultrasound and the virtual touch tissue quantification （VTQ） of acoustic radiation force impulse. Methods： Sixty-two patients with 96 thyroid solid nodules were enrolled into this prospective study （the final pathology diagnosis was confirmed by thyroidectomy）. Analysis of contrast enhancement characteristics, intensity-time curve parameters combination VTQ parameters for differential diagnosis of thyroid benign and malignant nodules. Results： Fifty nodular goiter, 15 adenoma, 31 papillary carcinoma, according to Chi- square test analysis with three types, enhanced degree, enhanced shape, peripheral enhancement had significant statistical dif- ference （P〈0.01）. In differential benign and malignant nodules aspect, the parameters of RS-Ratio, IMAX-Ratio AUC was rela- tively larger than others in the time-intensity curve （P〈0.01）, VTQ parameter SWV and SWV-Ratio AUC was larger than the RS-Ratio, IMAX-Ratio. Conclusion： The contrast-enhanced ultrasound pattern has great value in identification of thyroid nod- ule pathological type. The VTQ technology has greater value than the intensity-time curve in determination of whether a thy- roid nodule was benign or malignant.